PMID- 22458544
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20140417
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 19
IP  - 3
DP  - 2014 May
TI  - Serum brain-derived neurotrophic factor levels were reduced during 
      methamphetamine early withdrawal.
PG  - 482-5
LID - 10.1111/j.1369-1600.2012.00444.x [doi]
AB  - Methamphetamine (METH) abuse is an increasing public health problem worldwide. 
      Many of the METH-induced physical and mental problems are associated with the 
      neurotoxic effects of METH. Animal studies have shown that brain-derived 
      neurotrophic factor (BDNF) decreased after repeated amphetamine administration 
      and increased at 30 and 90 days from psychostimulant withdrawal, suggesting that 
      there might be a psychostimulant-induced neuroprotective dysfunction followed by 
      a neuroadaptive process in the brain. However, current research on the role of 
      BDNF in human METH addiction is limited, particularly during early withdrawal. 
      The aim of this study was to assess the serum BDNF levels in METH abusers during 
      the early withdrawal stage. Two groups of subjects were enrolled: (1) 59 DSM-IV 
      METH abusers confirmed by board-certified psychiatrists during the first 3 weeks 
      of withdrawal; (2) 59 age- and sex-matched healthy controls. We found that serum 
      BDNF levels were significantly and constantly lower in the METH abusers during 
      early withdrawal than those of the healthy controls. This indicates that METH 
      abusers might have severe BDNF dysfunction and an impaired neuroprotective 
      function after repetitive METH misuse.
CI  - (c) 2012 The Authors, Addiction Biology (c) 2012 Society for the Study of Addiction.
FAU - Chen, Pao-Huan
AU  - Chen PH
AD  - Department of Psychiatry and Psychiatric Research Center, Taipei Medical 
      University Hospital, Taiwan, Department of Addiction Science, Taipei City 
      Psychiatric Center, Taipei City Hospital, Taiwan, Department of Psychiatry, 
      School of Medicine, Taipei Medical University, Taiwan, Department of Psychiatry, 
      Cathay General Hospital, Taiwan Department of General Psychiatry, Taipei City 
      Psychiatric Center, Taipei City Hospital, Taiwan.
FAU - Huang, Ming-Chi
AU  - Huang MC
FAU - Lai, Ying-Ching
AU  - Lai YC
FAU - Chen, Po-Yu
AU  - Chen PY
FAU - Liu, Hsing-Cheng
AU  - Liu HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120328
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamine-Related Disorders/*blood/rehabilitation
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - *Central Nervous System Stimulants
MH  - Female
MH  - Humans
MH  - Male
MH  - *Methamphetamine
OTO - NOTNLM
OT  - Addiction
OT  - brain-derived neurotrophic factor
OT  - human
OT  - methamphetamine
OT  - neuroprotection
OT  - withdrawal
EDAT- 2012/03/31 06:00
MHDA- 2014/12/17 06:00
CRDT- 2012/03/31 06:00
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1111/j.1369-1600.2012.00444.x [doi]
PST - ppublish
SO  - Addict Biol. 2014 May;19(3):482-5. doi: 10.1111/j.1369-1600.2012.00444.x. Epub 
      2012 Mar 28.