PMID- 22459201
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20131121
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 220
IP  - 1-3
DP  - 2012 Jul 10
TI  - Examining the effect of dl-3,4-methylenedioxymethamphetamine (MDMA) and 
      methamphetamine on the Standardized Field Sobriety Tests.
PG  - e33-6
LID - 10.1016/j.forsciint.2012.02.025 [doi]
AB  - dl-3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine are commonly used 
      illicit drugs that are thought to impair driving ability. The Standardized Field 
      Sobriety Tests (SFSTs) are utilized widely to detect impairment associated with 
      drugs other than alcohol in drivers, although limited evidence concerning MDMA 
      and methamphetamine consumption on SFST performance exists. The aim of this study 
      was to evaluate whether the SFSTs were a sensitive measure for identifying the 
      presence of the specific isomer d-methamphetamine and MDMA. In a double-blind, 
      within-subject, counter-balanced and placebo-controlled study, 58 healthy and 
      abstinent recreational drugs users were administered three treatments: 100mg of 
      MDMA, 0.42 mg/kg d-methamphetamine, and placebo. For each condition the SFSTs 
      were administered at 4 and 25 h post treatment. d-methamphetamine was not found 
      to significantly impair SFST performance unlike MDMA, which significantly 
      impaired SFST performance in comparison to placebo with 22% of the sample failing 
      the test at the 4h testing time-point. No differences were observed at the 25 h 
      testing time-point for any of the conditions. It was concluded that the SFSTs are 
      not efficient in identifying the presence of low level d-methamphetamine, and are 
      significantly better at detecting the presence of MDMA at the levels assessed.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Downey, Luke A
AU  - Downey LA
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Hawthorn, Victoria, 3122, Australia. luke.a.downey@gmail.com
FAU - King, Rebecca
AU  - King R
FAU - Papafotiou, Katherine
AU  - Papafotiou K
FAU - Swann, Phillip
AU  - Swann P
FAU - Ogden, Edward
AU  - Ogden E
FAU - Stough, Con
AU  - Stough C
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120328
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Adult
MH  - Automobile Driving/*legislation & jurisprudence
MH  - Dextroamphetamine/*administration & dosage/blood
MH  - Double-Blind Method
MH  - Female
MH  - Forensic Toxicology
MH  - Hallucinogens/*administration & dosage/blood
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/blood
MH  - Neurologic Examination/drug effects
MH  - Nystagmus, Physiologic/drug effects
MH  - Postural Balance/drug effects
MH  - Substance Abuse Detection/*instrumentation
MH  - Walking
MH  - Young Adult
EDAT- 2012/03/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/03/31 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2011/11/17 00:00 [revised]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0379-0738(12)00101-6 [pii]
AID - 10.1016/j.forsciint.2012.02.025 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2012 Jul 10;220(1-3):e33-6. doi: 
      10.1016/j.forsciint.2012.02.025. Epub 2012 Mar 28.