PMID- 22459244
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - Associations of plasma von Willebrand factor ristocetin cofactor activity and 
      5-hydroxyindole acetic acid concentrations with blood flow in lower-leg arteries 
      in Japanese type 2 diabetic patients with normal ankle-brachial index.
PG  - 113-7
LID - 10.1016/j.jdiacomp.2012.02.003 [doi]
AB  - AIMS: To evaluate the associations of circulating levels of proinflammatory 
      molecules and endothelial factors with blood flow in lower-leg arteries in 
      diabetic patients with normal ankle-brachial index (ABI>0.9). METHODS: We 
      enrolled 123 type 2 diabetic patients with normal ABI and 30 age-matched 
      nondiabetic subjects consecutively admitted to our hospital. Flow volume and 
      resistive index, an index of peripheral vascular resistance, at the popliteal 
      artery were evaluated using gated two-dimensional cine-mode phase-contrast 
      magnetic resonance imaging. An automatic device was used to measure ABI and 
      brachial-ankle pulse-wave velocity (baPWV) for evaluation of arterial stiffness. 
      Plasma soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte 
      chemoattractant protein-1 (MCP-1) concentrations, serum high-sensitivity 
      C-reactive protein (hsCRP) levels, plasma von Willebrand factor ristocetin 
      cofactor activity (VWF), and plasma vasoconstrictor serotonin metabolite 
      5-hydroxyindole acetic acid (5-HIAA) concentrations were measured. RESULTS: 
      Diabetic patients had higher baPWV (P<.0001), resistive index (P<.0001), sICAM-1 
      (P<.0001), MCP-1 (P=.0224), log hsCRP (P<.0001), VWF (P<.0001), 5-HIAA (P=.0015), 
      and lower blood flow (P<.0001) than nondiabetic subjects. VWF (P=.0019) or 5-HIAA 
      (P=.0011), but not sICAM-1, MCP-1, and log hsCRP, was negatively correlated with 
      blood flow in diabetic patients. A multivariate analysis revealed that the 
      significant independent determinants of blood flow were hypertension, use of 
      renin-angiotensin system inhibitors, VWF and 5-HIAA (r(2)=0.198, P<.0001) in 
      diabetic patients. CONCLUSIONS: Plasma VWF and 5-HIAA concentrations are 
      associated with blood flow and are involved in the pathogenesis of impaired 
      peripheral circulation due to higher arterial stiffness and greater vascular 
      resistance in lower-leg arteries in diabetic patients with normal ABI.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Murase, Hiroshi
AU  - Murase H
AD  - Department of Internal Medicine, Daiyukai General Hospital, 1-9-9 Sakura, 
      Ichinomiya, Aichi 491-8551, Japan.
FAU - Suzuki, Eiji
AU  - Suzuki E
FAU - Tajima, Yoshitaka
AU  - Tajima Y
FAU - Hayashi, Kanako
AU  - Hayashi K
FAU - Nakamura, Tomohiko
AU  - Nakamura T
FAU - Noritake, Nobuyasu
AU  - Noritake N
FAU - Takeda, Jun
AU  - Takeda J
LA  - eng
PT  - Journal Article
DEP - 20120328
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Cytokines)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (von Willebrand Factor)
RN  - 1404-55-3 (Ristocetin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
SB  - IM
MH  - Aged
MH  - *Ankle Brachial Index
MH  - Antihypertensive Agents/therapeutic use
MH  - Arteries/drug effects/physiopathology
MH  - Asian People
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy/physiopathology
MH  - Diabetic Angiopathies/blood/drug therapy/physiopathology
MH  - Female
MH  - Humans
MH  - Hydroxyindoleacetic Acid/*blood
MH  - Hypertension/blood/drug therapy/physiopathology
MH  - Hypoglycemic Agents/therapeutic use
MH  - Leg/*blood supply/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Ristocetin/*blood
MH  - Vascular Resistance
MH  - von Willebrand Factor/*analysis
EDAT- 2012/03/31 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/03/31 06:00
PHST- 2011/05/08 00:00 [received]
PHST- 2012/02/17 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - S1056-8727(12)00005-0 [pii]
AID - 10.1016/j.jdiacomp.2012.02.003 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2012 Mar-Apr;26(2):113-7. doi: 
      10.1016/j.jdiacomp.2012.02.003. Epub 2012 Mar 28.