PMID- 22459470
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20220331
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 25
IP  - 2
DP  - 2012 Apr
TI  - The effect of hydro alcoholic extract of Juglans regia leaves in 
      streptozotocin-nicotinamide induced diabetic rats.
PG  - 407-11
AB  - Phytotherapy has been achieved to maintain glycemic control in patients with 
      diabetes mellitus. The present study was conducted to evaluate the 
      antihyperglycemic properties of the Juglans regia leaf extract in 
      streptozotocin-nicotinamide induced diabetic rats. Nicotinamide was injected 
      intraperitonealy (i.p.) 15 min before the injection of Streptozotocin (i.p.). One 
      week after induction of diabetes, oral treatment started with extract of Juglans 
      regia and Metformin and continued for 4 weeks. Fasting blood sugar, body weight, 
      serum lipids and insulin level were measured in different groups. A significant 
      reduction of glucose, HbA1c, total cholesterol and serum triglycerides were 
      detected after 4 weeks in rats treated with Juglans regia leaves compared to the 
      control groups. Thus, Juglans regia extract treatment showed potential 
      hypoglycemic and hypolipidemic effects in type 2 diabetic rats.
FAU - Mohammadi, Jamshid
AU  - Mohammadi J
AD  - Herbal Medicine Research Center, Department of Physiology, College of 
      Medicine,Yasouj University of Medical Sciences,Yasouj, Iran. 
      jamshidm2005@yahoo.com
FAU - Delaviz, Hamdollah
AU  - Delaviz H
FAU - Malekzadeh, Jan Mohammad
AU  - Malekzadeh JM
FAU - Roozbehi, Amrollah
AU  - Roozbehi A
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Extracts)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy
MH  - *Juglans
MH  - Male
MH  - Niacinamide/*pharmacology
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Plant Leaves
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin
EDAT- 2012/03/31 06:00
MHDA- 2012/06/12 06:00
CRDT- 2012/03/31 06:00
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
PST - ppublish
SO  - Pak J Pharm Sci. 2012 Apr;25(2):407-11.