PMID- 22459696
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20201126
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 47
IP  - 5
DP  - 2012 May
TI  - Analysis of early biochemical markers and regulation by tin protoporphyrin IX in 
      a model of spontaneous osteoarthritis.
PG  - 406-9
LID - 10.1016/j.exger.2012.03.005 [doi]
AB  - Age-related changes in joint tissues lead to osteoarthritis (OA). Detection of 
      early changes in OA patients may help to initiate treatments before the 
      establishment of irreversible joint destruction. STR/ort mice develop with age a 
      severe degenerative joint disease that resembles human OA thus allowing the 
      investigation of biochemical markers as well as new treatments in an accelerated 
      time frame. We have analyzed the changes in serum levels of different mediators 
      during the early phases of idiopathic OA in STR/ort mice. Serum levels of matrix 
      metalloproteinase-3 (MMP-3) but not those of tumor necrosis factor-alpha, 
      interleukin(IL)-1beta, IL-17 or prostaglandin E(2) correlated with histopathological 
      changes in knees of STR/ort mice at 9 weeks. Treatment of animals with tin 
      protoporphyrin IX (SnPP, 12 mg/kg/dayi.p.) for 4 weeks significantly reduced the 
      progression of OA. Our data suggest that MMP-3 is a sensitive biomarker to detect 
      early OA alterations and that SnPP could be a protective agent in OA.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Braza-Boils, Aitana
AU  - Braza-Boils A
AD  - Department of Pharmacology, and IDM, University of Valencia, Av. Vicent Andres 
      Estelles s/n, 46100 Burjasot, Valencia, Spain.
FAU - Ferrandiz, Maria Luisa
AU  - Ferrandiz ML
FAU - Terencio, Maria Carmen
AU  - Terencio MC
FAU - Alcaraz, Maria Jose
AU  - Alcaraz MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120317
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Biomarkers)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Metalloporphyrins)
RN  - 0 (Protoporphyrins)
RN  - DIO3JT9G2P (tin protoporphyrin IX)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/blood/*diagnosis/pathology/prevention & control
MH  - Biomarkers/blood
MH  - Clinical Enzyme Tests/methods
MH  - Disease Progression
MH  - Drug Evaluation, Preclinical/methods
MH  - Early Diagnosis
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Heme Oxygenase (Decyclizing)/antagonists & inhibitors
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Metalloporphyrins/*therapeutic use
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Osteoarthritis/blood/*diagnosis/pathology/prevention & control
MH  - Protoporphyrins/*therapeutic use
EDAT- 2012/03/31 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/03/31 06:00
PHST- 2011/12/15 00:00 [received]
PHST- 2012/02/08 00:00 [revised]
PHST- 2012/03/11 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - S0531-5565(12)00060-5 [pii]
AID - 10.1016/j.exger.2012.03.005 [doi]
PST - ppublish
SO  - Exp Gerontol. 2012 May;47(5):406-9. doi: 10.1016/j.exger.2012.03.005. Epub 2012 
      Mar 17.