PMID- 22461186
OWN - NLM
STAT- MEDLINE
DCOM- 20140613
LR  - 20211021
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 33
IP  - 9
DP  - 2013 Sep
TI  - Serum levels of selected chemokines in systemic lupus erythematosus patients.
PG  - 2423-7
LID - 10.1007/s00296-012-2393-5 [doi]
AB  - Chemokines promote leukocyte traffic into the site of inflammation. Serum levels 
      of monocyte chemotactic protein 1 (MCP-1), stromal cell-derived factor-1 (SDF-1), 
      interferon-gamma-inducible protein 10 (IP-10), and interleukin-8 (IL-8) were 
      evaluated in 48 treated women with systemic lupus erythematosus (SLE) and 
      mild-to-moderate disease severity. The results were compared between the whole 
      SLE group and the control (29 women). The relationships between chemokines, their 
      concentrations, and peripheral blood leukocyte count and between the chemokines 
      and individual leukocyte populations (polymorphonuclear leukocytes-PMNs, 
      lymphocytes-Ls, monocytes-Ms, eosinophils) counts were determined. The 
      relationships between the analyzed chemokines were also determined in the 
      control. SLE subjects had significantly higher MCP-1, SDF-1, IP-10, and lower 
      IL-8 concentrations compared to the control. Moderate, positive correlations 
      between MCP-1/SDF-1, SDF-1/IP-10 and a negative correlation between MCP-1/IL8 
      were observed in the patient group. Moderate, negative correlations were found 
      between SDF-1/total leukocyte count, SDF-1/absolute number of PMNs as well as 
      between IP-10/total leukocyte count, IP-10/absolute PMNs, Ls, and Ms counts in 
      peripheral blood of SLE group. We suggest that the obtained results and 
      correlations observed between the examined parameters might be used to monitor 
      SLE course and progression. However, further randomized clinical studies should 
      be carried out on in untreated and treated patients with SLE.
FAU - Hrycek, Eugeniusz
AU  - Hrycek E
AD  - Student Scientific Section at the Department of Internal, Autoimmune, and 
      Metabolic Diseases, Medical University of Silesia, ul. Medykow 14, 40-752 
      Katowice, Poland.
FAU - Franek, Andrzej
AU  - Franek A
FAU - Blaszczak, Edward
AU  - Blaszczak E
FAU - Dworak, Justyna
AU  - Dworak J
FAU - Hrycek, Antoni
AU  - Hrycek A
LA  - eng
PT  - Journal Article
DEP - 20120330
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (CXCL10 protein, human)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/blood
MH  - Chemokine CXCL10/blood
MH  - Chemokine CXCL12/blood
MH  - Chemokines/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-8/blood
MH  - Lupus Erythematosus, Systemic/*immunology
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2012/03/31 06:00
MHDA- 2014/06/15 06:00
CRDT- 2012/03/31 06:00
PHST- 2011/10/23 00:00 [received]
PHST- 2012/03/11 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2014/06/15 06:00 [medline]
AID - 10.1007/s00296-012-2393-5 [doi]
PST - ppublish
SO  - Rheumatol Int. 2013 Sep;33(9):2423-7. doi: 10.1007/s00296-012-2393-5. Epub 2012 
      Mar 30.