PMID- 22461468 OWN - NLM STAT- MEDLINE DCOM- 20120525 LR - 20210202 IS - 1528-0020 (Electronic) IS - 0006-4971 (Linking) VI - 119 IP - 13 DP - 2012 Mar 29 TI - IRIS: the unfortunate rainbow of HIV. PG - 2971-2 LID - 10.1182/blood-2012-01-403683 [doi] AB - In this issue of Blood, Mahnke and colleagues identify polyfunctional CD4(+) T-cell responses directed against specific opportunistic pathogens in HIV-infected patients who develop immune reconstitution inflammatory syndrome (IRIS) after initiation of antiretroviral therapy (ART). This work provides a mechanistic advance to our understanding of IRIS pathogenesis. FAU - Chahroudi, Ann AU - Chahroudi A AD - Emory University. FAU - Silvestri, Guido AU - Silvestri G LA - eng PT - Comment PT - Journal Article PL - United States TA - Blood JT - Blood JID - 7603509 SB - IM CON - Blood. 2012 Mar 29;119(13):3105-12. PMID: 22219223 MH - CD4-Positive T-Lymphocytes/*immunology MH - *Cell Proliferation MH - Female MH - HIV Infections/*immunology MH - HIV-1/*immunology MH - Humans MH - Immune Reconstitution Inflammatory Syndrome/*immunology MH - Male EDAT- 2012/03/31 06:00 MHDA- 2012/05/26 06:00 CRDT- 2012/03/31 06:00 PHST- 2012/03/31 06:00 [entrez] PHST- 2012/03/31 06:00 [pubmed] PHST- 2012/05/26 06:00 [medline] AID - S0006-4971(20)49158-X [pii] AID - 10.1182/blood-2012-01-403683 [doi] PST - ppublish SO - Blood. 2012 Mar 29;119(13):2971-2. doi: 10.1182/blood-2012-01-403683.