PMID- 22461837
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20211021
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2012
DP  - 2012
TI  - Influence of dendritic cells on B-cell responses during HIV infection.
PG  - 592187
LID - 10.1155/2012/592187 [doi]
LID - 592187
AB  - Dendritic cells (DCs) modulate B-cell differentiation, activation, and survival 
      mainly through production of growth factors such as B lymphocyte stimulator 
      (BLyS/BAFF). DC populations have been reported to be affected in number, 
      phenotype and function during HIV infection and such alterations may contribute 
      to the dysregulation of the B-cell compartment. Herein, we reflect on the 
      potential impact of DC on the pathogenesis of HIV-related B cell disorders, and 
      how DC status may modulate the outcome of mucosal B cell responses against HIV, 
      which are pivotal to the control of disease. A concept that could be extrapolated 
      to the overall outcome of HIV disease, whereby control versus progression may 
      reside in the host's capacity to maintain DC homeostasis at mucosal sites, where 
      DC populations present an inherent capacity of modulating the balance between 
      tolerance and protection, and are amongst the earliest cell types to be exposed 
      to the virus.
FAU - Poudrier, Johanne
AU  - Poudrier J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier de 
      l'Universite de Montreal, Hopital Notre-Dame, 2099 Alexandre De Seve, Montreal, 
      QC, Canada H2L 2W5. johanne.poudrier@crchum.qc.ca
FAU - Chagnon-Choquet, Josiane
AU  - Chagnon-Choquet J
FAU - Roger, Michel
AU  - Roger M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120222
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (B-Cell Activating Factor)
SB  - IM
MH  - Animals
MH  - B-Cell Activating Factor/immunology
MH  - B-Lymphocytes/*immunology/pathology/virology
MH  - Dendritic Cells/*immunology/pathology/virology
MH  - Disease Progression
MH  - HIV/*immunology
MH  - HIV Infections/*immunology/pathology/virology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Mucosal
MH  - Mice
MH  - Mice, Transgenic
MH  - Mucous Membrane/*immunology/pathology/virology
MH  - T-Lymphocytes, Regulatory/immunology/pathology/virology
PMC - PMC3296217
EDAT- 2012/03/31 06:00
MHDA- 2013/03/02 06:00
PMCR- 2012/02/22
CRDT- 2012/03/31 06:00
PHST- 2011/10/03 00:00 [received]
PHST- 2011/12/11 00:00 [revised]
PHST- 2011/12/12 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
PHST- 2012/02/22 00:00 [pmc-release]
AID - 10.1155/2012/592187 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2012;2012:592187. doi: 10.1155/2012/592187. Epub 2012 Feb 22.