PMID- 22462418
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20120402
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Apr
TI  - Different clinical features in patients with ankylosing spondylitis from southern 
      and northern China.
PG  - 154-62
LID - 10.1111/j.1756-185X.2011.01697.x [doi]
AB  - AIMS: To describe clinical features of patients with ankylosing spondylitis (AS) 
      from southern and northern China, and investigate the effects of onset age, 
      gender and regional differences on disease phenotype. METHODS: Totally 113 AS 
      patients from southern China and 121 AS patients from northern China were 
      analyzed retrospectively. RESULTS: In southern and northern groups, low back pain 
      was more frequent among initial symptoms (54.9% vs. 7.7%; 52.4% vs. 11.4%), while 
      peripheral arthritis (15.7% vs. 35.9%; 22.2% vs. 68.6%) was less common in male 
      adult AS (AAS) than in male juvenile AS (JAS) patients, respectively. Compared to 
      those in the northern group, diagnostic delay was longer (7.3 vs. 3.5 years) and 
      the prevalence of human leukocyte antigen (HLA)-B27 was higher in the southern 
      group (96.5% vs. 83.5%). Sacroiliitis grade 2 was more frequent (51.3% vs. 
      36.4%), while sacroiliitis grade 3 (32.7% vs. 53.7%), buttock pain (5.3% vs. 
      13.2%), knee (20.4% vs. 33.1%) and ankle (3.5% vs. 11.6%) arthritis were less 
      frequent in the southern group. Diagnostic delay of southern JAS was longer than 
      that of northern JAS regardless of gender. Both sacroiliitis grade 3 and 
      peripheral arthritis were less frequent in southern male JAS than in northern 
      male JAS. Diagnostic delay was longer, sacroiliitis grade 2 was more frequent, 
      while sacroiliitis grade 3 was less frequent in southern male AAS than those in 
      northern male AAS. CONCLUSION: Significant diagnostic delay and higher prevalence 
      of HLA-B27 were found in southern AS patients. The prevalence of buttock pain and 
      peripheral arthritis at disease onset in northern AS was more frequent than in 
      southern AS patients.
CI  - (c) 2011 The Authors. International Journal of Rheumatic Diseases (c) 2011 Asia 
      Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty 
      Ltd.
FAU - Ma, Hai-jun
AU  - Ma HJ
AD  - Division of Rheumatology, The First Affiliated Hospital, Xinxiang Medical 
      University, Weihui, China.
FAU - Yin, Qing-feng
AU  - Yin QF
FAU - Hu, Feng-ping
AU  - Hu FP
FAU - Guo, Ming-hao
AU  - Guo MH
FAU - Liu, Xiang-dong
AU  - Liu XD
FAU - Liu, Yun
AU  - Liu Y
FAU - Xu, Qing-yu
AU  - Xu QY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111204
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Arthritis/*diagnosis/epidemiology/genetics
MH  - China/epidemiology
MH  - Comorbidity
MH  - Delayed Diagnosis/statistics & numerical data
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Geography
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Joints/pathology/physiopathology
MH  - Low Back Pain/*diagnosis/epidemiology/genetics
MH  - Male
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Spondylitis, Ankylosing/*diagnosis/epidemiology/genetics
MH  - Young Adult
EDAT- 2012/04/03 06:00
MHDA- 2012/07/27 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - 10.1111/j.1756-185X.2011.01697.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2012 Apr;15(2):154-62. doi: 10.1111/j.1756-185X.2011.01697.x. 
      Epub 2011 Dec 4.