PMID- 22462708
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20220316
IS  - 1933-0715 (Electronic)
IS  - 1933-0707 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Apr
TI  - Stereotactic endoscopic resection and surgical management of a subependymal giant 
      cell astrocytoma: case report.
PG  - 417-20
LID - 10.3171/2011.12.PEDS11349 [doi]
AB  - Subependymal giant cell astrocytomas (SEGAs) are benign tumors, most commonly 
      associated with tuberous sclerosis complex (TSC). Arising from the lateral 
      ependymal surface, these tumors may obstruct one or both foramina of Monro, 
      resulting in hydrocephalus and often requiring treatment. Although 
      interhemispheric-transcallosal and transcortical-transventricular approaches have 
      been the standard methods for resecting these tumors, advances in neuroendoscopic 
      techniques have expanded SEGAs as a potential target for endoscopic resection. 
      The authors present a case of an endoscopically resected SEGA with stereotactic 
      guidance in a 4-year-old girl with TSC. A gross-total resection of an enlarging 
      SEGA was achieved. This represents one of the early case reports of 
      endoscopically resected SEGAs. Although recent advances in medical treatment for 
      SEGAs with mammalian target of rapamycin (mTOR) pathway inhibitors have shown 
      promising initial results, the long-term safety and efficacy of mTOR inhibitors 
      has yet to be determined. The propensity of these tumors to cause obstructive 
      hydrocephalus requires that a surgical option remain. Neuroendoscopic approaches 
      may allow a safe and effective technique.
FAU - Rodgers, Shaun D
AU  - Rodgers SD
AD  - Department of Neurosurgery, Division of Pediatric Neurosurgery, New York 
      University Langone Medical Center, New York, NY 10016, USA. 
      Shaun.Rodgers@nyumc.org
FAU - Bassani, Luigi
AU  - Bassani L
FAU - Weiner, Howard L
AU  - Weiner HL
FAU - Harter, David H
AU  - Harter DH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Neurosurg Pediatr
JT  - Journal of neurosurgery. Pediatrics
JID - 101463759
SB  - IM
MH  - Astrocytoma/complications/*diagnosis/pathology/*surgery
MH  - Brain Neoplasms/complications/*diagnosis/pathology/*surgery
MH  - Child, Preschool
MH  - Endoscopy/*methods
MH  - Humans
MH  - Hydrocephalus/etiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Stereotaxic Techniques
MH  - Treatment Outcome
EDAT- 2012/04/03 06:00
MHDA- 2012/05/17 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - 10.3171/2011.12.PEDS11349 [doi]
PST - ppublish
SO  - J Neurosurg Pediatr. 2012 Apr;9(4):417-20. doi: 10.3171/2011.12.PEDS11349.