PMID- 22464577
OWN - NLM
STAT- MEDLINE
DCOM- 20130729
LR  - 20120402
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 24
IP  - 4
DP  - 2012 Apr
TI  - [Effects of extracorporeal membrane oxygenation on hemodynamics in acute right 
      heart failure in dogs].
PG  - 229-32
AB  - OBJECTIVE: To investigate the effects of extracorporeal membrane oxygenation 
      (ECMO) on the hemodynamics in dogs with acute right heart failure. METHODS: Ten 
      healthy adult male dogs (weighted 20-25 kg) were randomly divided into two 
      groups: acute right heart failure group (n = 5) and ECMO group (n = 5). Under 
      anesthesia, dogs were underwent thoracotomy, then the catheters were placed in 
      the right atrium, right ventricle, and pulmonary artery, for measuring the 
      relevant pressures, including right arterial pressure (RAP), right ventricular 
      pressure (RVP), and pulmonary artery pressure (PAP). The vascular ultrasound 
      probe were placed on the aorta and pulmonary artery for measuring the cardiac 
      output (CO) and pulmonary artery flow rate (QPA). Then, a baseline measurement 
      was acquired. The femoral artery and femoral vein were cannulated and used for 
      the venoarterial extracorporeal membrane oxygenation (VA-ECMO), and then 
      connected to extracorporeal circuit, which was initially primed. The pulmonary 
      artery was progressively ligated to decrease blood flow until QPA was 60%, 40%, 
      and 0% of baseline in both groups. The above flow conditions were respectively 
      maintained for 30 minutes, after which hemodynamic data were collected. RESULTS: 
      The baseline hemodynamic measurements were not different between acute right 
      heart failure group and ECMO group. After ligating the pulmonary artery, compared 
      with baseline, CO (L/min) decreased significantly at 60% and 40% QPA in acute 
      right heart failure group (1.80 +/- 0.19, 1.48 +/- 0.22 vs. 3.24 +/- 0.23, both P < 
      0.05), and significantly lower than that of ECMO group (60%QPA: 1.80 +/- 0.19 vs. 
      3.24 +/- 0.35; 40%QPA: 1.48 +/- 0.22 vs. 3.20 +/- 0.37, both P < 0.05). CO was not 
      significantly different from baseline in ECMO group at 60%, 40% and 0% QPA (3.24 
      +/- 0.35, 3.20 +/- 0.37, 3.12 +/- 0.28 vs. 3.44 +/- 0.32, all P>0.05). PAP, RAP and RVP 
      (all mm Hg, 1 mm Hg = 0.133 kPa) were significantly elevated in acute right heart 
      failure group at 60% and 40% QPA compared with baseline (PAP: 36.2 +/- 5.3, 39.8 +/- 
      5.4 vs. 17.4 +/- 2.7; RAP: 11.2 +/- 2.8, 12.8 +/- 2.6 vs. 4.4 +/- 1.7; RVP: 25.6 +/- 4.9, 
      27.8 +/- 4.5 vs. 11.6 +/- 1.8, all P < 0.05), and significantly higher than those of 
      ECMO group (60%QPA: PAP 36.2 +/- 5.3 vs. 23.2 +/- 5.2, RAP 11.2 +/- 2.8 vs. 6.2 +/- 2.3, 
      RVP 25.6 +/- 4.9 vs. 15.2 +/- 3.5; 40%QPA: PAP 39.8 +/- 5.4 vs. 24.4 +/- 4.8, RAP 12.8 +/- 
      2.6 vs. 7.0 +/- 2.4, RVP 27.8 +/- 4.5 vs. 16.8 +/- 4.2, all P < 0.05), whereas mean 
      artery pressure (MAP, mm Hg) was significantly lowered compared with that of 
      baseline (81.2 +/- 15.8, 62.2 +/- 14.4 vs. 128.6 +/- 16.4, both P < 0.05), and it was 
      lower than that of ECMO group (60%QPA: 81.2 +/- 15.8 vs. 128.0 +/- 26.5; 40%QPA: 62.2 
      +/- 14.4 vs. 124.6 +/- 25.4, both P < 0.05). At 60%, 40% and 0% QPA in ECMO group, 
      whereas heart rate (HR, beats/min), PAP, RAP and RVP were slightly increased 
      compared with those of baseline (HR: 161.4 +/- 14.8, 160.6 +/- 13.1, 157.6 +/- 11.9 vs. 
      152.6 +/- 14.5; PAP: 23.2 +/- 5.2, 24.4 +/- 4.8, 25.2 +/- 6.2 vs. 18.8 +/- 3.4; RAP: 6.2 +/- 
      2.3, 7.0 +/- 2.4, 7.6 +/- 4.2 vs. 4.6 +/- 1.5; RVP: 15.2 +/- 3.5, 16.8 +/- 4.2, 16.2 +/- 3.3 
      vs. 12.2 +/- 2.3), but MAP was slightly decreased (128.0 +/- 26.5, 124.6 +/- 25.4, 
      121.2 +/- 21.4 vs. 135.8 +/- 22.2), however, all differences were not statistically 
      significant (all P>0.05). CONCLUSION: These findings demonstrate that VA-ECMO 
      could be helpful in improving cardiac function, and maintaining stability of 
      hemodynamics in dogs with acute right heart failure.
FAU - Zheng, Jun-bo
AU  - Zheng JB
AD  - Intensive Care Unit, the Second Affiliated Hospital of Harbin Medical University, 
      Harbin 150086, Heilongjiang, China.
FAU - Yu, Kai-jiang
AU  - Yu KJ
FAU - Ye, Ming
AU  - Ye M
FAU - Wang, Hong-liang
AU  - Wang HL
FAU - Jiang, Xue-song
AU  - Jiang XS
FAU - Liu, Hai-tao
AU  - Liu HT
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
SB  - IM
MH  - Animals
MH  - Dogs
MH  - *Extracorporeal Membrane Oxygenation
MH  - Heart Failure/*physiopathology/*therapy
MH  - Hemodynamics
MH  - Male
MH  - Ventricular Dysfunction, Right/physiopathology/therapy
EDAT- 2012/04/03 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Apr;24(4):229-32.