PMID- 22464668
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20220330
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
VI  - 129
IP  - 4
DP  - 2012 Apr
TI  - The role of dendritic cells in asthma.
PG  - 889-901
LID - 10.1016/j.jaci.2012.02.028 [doi]
AB  - Dendritic cells (DCs) are known to play a central role in sensing the presence of 
      foreign antigens and infectious agents and in initiating appropriate immune 
      responses. More recently, an additional role has been discovered for DCs in 
      determining whether the response to potential environmental allergens will be one 
      of tolerance or whether a vigorous response along allergic pathways will be 
      initiated. This review discusses ways in which DCs participate specifically in 
      initiating allergic responses, particularly those associated with allergic 
      asthma, and how interventions focused on DCs might lead to new therapeutic 
      approaches to asthma.
CI  - Copyright (c) 2012 American Academy of Allergy, Asthma & Immunology. Published by 
      Mosby, Inc. All rights reserved.
FAU - Gill, Michelle Ann
AU  - Gill MA
AD  - Department of Pediatrics, University of Texas Southwestern Medical Center, 
      Dallas, TX, USA. Michelle.Gill@UTSouthwestern.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Allergens)
RN  - 0 (Interferon-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/*immunology/metabolism/therapy
MH  - Dendritic Cells/*immunology/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Inflammation/immunology/metabolism
MH  - Interferon-alpha/metabolism
MH  - Lung/cytology/immunology/metabolism
MH  - Molecular Targeted Therapy
MH  - Th2 Cells/immunology
MH  - Viruses/immunology
EDAT- 2012/04/03 06:00
MHDA- 2012/07/10 06:00
CRDT- 2012/04/03 06:00
PHST- 2011/11/23 00:00 [received]
PHST- 2012/02/21 00:00 [revised]
PHST- 2012/02/23 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
AID - S0091-6749(12)00358-2 [pii]
AID - 10.1016/j.jaci.2012.02.028 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2012 Apr;129(4):889-901. doi: 10.1016/j.jaci.2012.02.028.