PMID- 22464669
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20211021
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
VI  - 129
IP  - 4
DP  - 2012 Apr
TI  - The role of dendritic cells in food allergy.
PG  - 921-8
LID - 10.1016/j.jaci.2012.01.080 [doi]
AB  - In recent years, our understanding of the initiation of T(H)2-type immunity has 
      increased significantly, yet the mechanism behind the induction of T(H)2 
      responses and allergic sensitization to food antigens largely remains an enigma. 
      Dendritic cells (DCs) were first described almost 4 decades ago and have since 
      been recognized as the most important antigen-presenting cells and crucial in the 
      induction of T-cell differentiation. Here we discuss our current knowledge of the 
      role of DCs in food allergy. In both murine models and allergic patients, 
      characteristics of DCs have been identified that might play a role in 
      sensitization to food and enhance susceptibility to food allergy. In addition, it 
      has now been shown that several allergens, including some from foods, can 
      directly activate DCs to induce T(H)2 skewing. Other cell types with innate 
      immune functions, such as epithelial cells and basophils, might also be involved 
      in sensing of food allergens in human subjects, and interaction of DCs with these 
      cells might facilitate sensitization. DCs appear to play an important role in 
      allergen-specific immunotherapy and could be an attractive target for tolerance 
      induction in patients with food allergy. Further characterization of differences 
      in DC responses between human food-allergic and nonallergic subjects is necessary 
      to gain a better insight into the role of DCs in sensitization and tolerance to 
      food allergens.
CI  - Copyright (c) 2012 American Academy of Allergy, Asthma & Immunology. Published by 
      Mosby, Inc. All rights reserved.
FAU - Ruiter, Bert
AU  - Ruiter B
AD  - Center for Immunology and Inflammatory Diseases and the Food Allergy Center, 
      Harvard Medical School, Boston, MA, USA. bruiter@partners.org
FAU - Shreffler, Wayne G
AU  - Shreffler WG
LA  - eng
GR  - L40 CA117818/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Desensitization, Immunologic
MH  - Food Hypersensitivity/*immunology/therapy
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Innate/immunology
MH  - Th2 Cells/immunology
EDAT- 2012/04/03 06:00
MHDA- 2012/07/10 06:00
CRDT- 2012/04/03 06:00
PHST- 2011/11/09 00:00 [received]
PHST- 2012/01/19 00:00 [revised]
PHST- 2012/01/19 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
AID - S0091-6749(12)00355-7 [pii]
AID - 10.1016/j.jaci.2012.01.080 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2012 Apr;129(4):921-8. doi: 10.1016/j.jaci.2012.01.080.