PMID- 22465524
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20120430
IS  - 1872-8111 (Electronic)
IS  - 0168-0102 (Linking)
VI  - 73
IP  - 2
DP  - 2012 Jun
TI  - Principal Fourier component of motion stimulus dominates the initial optokinetic 
      response in mice.
PG  - 133-41
LID - 10.1016/j.neures.2012.03.007 [doi]
AB  - Optokinetic responses (OKRs) are reflexive eye movements elicited by a moving 
      visual pattern, and have been recognized in a variety of species. Several 
      brainstem and cortical structures are known to be implicated in the generation of 
      OKRs in primates, while the OKRs of afoveate mammals have been posited to be 
      dominated by subcortical structures. To understand the subcortical mechanism 
      underlying OKRs, the initial OKRs to horizontal quarter-wavelength steps applied 
      to vertical grating patterns were studied in adult C57BL/6J mice under the 
      monocular viewing conditions. The initial OKRs to sinusoidal gratings showed 
      directional asymmetry with temporal-to-nasal predominance, a common 
      characteristic of afoveate mammals that uses the subcortical structures to elicit 
      OKRs. We then examined whether the OKRs of afoveate mammals are driven by the 
      same visual features of the moving images as those in primates. The OKRs in mice 
      were elicited by using the missing fundamental (mf) stimuli and its variants that 
      had been used to understand the mechanism(s) underlying the cortical control of 
      eye movements in primates. We obtained the results indicating that the OKRs of 
      mice are driven by the principal Fourier component of moving visual image as in 
      primates despite the differences in neural circuitries.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All 
      rights reserved.
FAU - Sugita, Yuko
AU  - Sugita Y
AD  - Department of Integrative Brain Science, Graduate School of Medicine, Kyoto 
      University, Japan.
FAU - Miura, Kenichiro
AU  - Miura K
FAU - Kawano, Kenji
AU  - Kawano K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120323
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
SB  - IM
MH  - Animals
MH  - *Fourier Analysis
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motion Perception/*physiology
MH  - Nystagmus, Optokinetic/*physiology
MH  - Photic Stimulation/*methods
MH  - Reaction Time/*physiology
EDAT- 2012/04/03 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/04/03 06:00
PHST- 2011/11/08 00:00 [received]
PHST- 2012/03/13 00:00 [revised]
PHST- 2012/03/14 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - S0168-0102(12)00057-0 [pii]
AID - 10.1016/j.neures.2012.03.007 [doi]
PST - ppublish
SO  - Neurosci Res. 2012 Jun;73(2):133-41. doi: 10.1016/j.neures.2012.03.007. Epub 2012 
      Mar 23.