PMID- 22465806
OWN - NLM
STAT- MEDLINE
DCOM- 20130520
LR  - 20211021
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Print)
IS  - 0300-9572 (Linking)
VI  - 83
IP  - 8
DP  - 2012 Aug
TI  - Coenzyme Q10 levels are low and associated with increased mortality in 
      post-cardiac arrest patients.
PG  - 991-5
LID - 10.1016/j.resuscitation.2012.03.023 [doi]
AB  - AIM: Survival after cardiac arrest (CA) is limited by the profound neurologic 
      insult from ischemia-reperfusion injury. Therapeutic options are limited. 
      Previous data suggest a benefit of coenzyme Q(10) (CoQ(10)) in post-arrest 
      patients. We hypothesized that plasma CoQ(10) levels would be low after CA and 
      associated with poorer outcomes. METHODS: Prospective observational study of 
      post-arrest patients presenting to a tertiary care center. CoQ(10) levels were 
      drawn 24h after return of spontaneous circulation (ROSC) and compared to healthy 
      controls. Levels of inflammatory cytokines and biomarkers were analyzed. Primary 
      endpoints were survival to discharge and neurologic status at time of discharge. 
      RESULTS: 23 CA subjects and 16 healthy controls were enrolled. CoQ(10) levels in 
      CA patients (0.28 mumol L(-1), inter-quartile range (IQR): 0.22-0.39) were 
      significantly lower than in controls (0.75 mumol L(-1), IQR: 0.61-1.08, p<0.0001). 
      The mean CoQ(10) level in CA patients who died was significantly lower than in 
      those who survived (0.27 vs 0.47 mumol L(-1), p = 0.007). There was a significant 
      difference in median CoQ(10) level between patients with a good vs poor 
      neurological outcome (0.49 mumol L(-1), IQR: 0.30-0.67 vs 0.27 mumol L(-1), IQR: 
      0.21-0.30, p = 0.02). CoQ(10) was a statistically significant predictor of poor 
      neurologic outcome (adjusted p = 0.02) and in-hospital mortality (adjusted p = 
      0.026). CONCLUSION: CoQ(10) levels are low in human subjects with ROSC after 
      cardiac arrest as compared to healthy controls. CoQ(10) levels were lower in 
      those who died, as well as in those with a poor neurologic outcome.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Cocchi, Michael N
AU  - Cocchi MN
AD  - Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, 
      MA 02215, United States. mcocchi@bidmc.harvard.edu
FAU - Giberson, Brandon
AU  - Giberson B
FAU - Berg, Katherine
AU  - Berg K
FAU - Salciccioli, Justin D
AU  - Salciccioli JD
FAU - Naini, Ali
AU  - Naini A
FAU - Buettner, Catherine
AU  - Buettner C
FAU - Akuthota, Praveen
AU  - Akuthota P
FAU - Gautam, Shiva
AU  - Gautam S
FAU - Donnino, Michael W
AU  - Donnino MW
LA  - eng
GR  - F32 AI081513/AI/NIAID NIH HHS/United States
GR  - K23 AR055664/AR/NIAMS NIH HHS/United States
GR  - NIH K23AR055664/AR/NIAMS NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - NIH F32AI081513/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120328
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
CIN - Resuscitation. 2012 Aug;83(8):928-9. PMID: 22640977
MH  - Aged
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Heart Arrest/*blood/mortality
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Patient Discharge
MH  - Prospective Studies
MH  - Survival Analysis
MH  - Ubiquinone/*analogs & derivatives/blood
PMC - PMC3658101
MID - NIHMS459895
COIS- Conflict of interest statement None of the authors declare any conflict of 
      interests.
EDAT- 2012/04/03 06:00
MHDA- 2013/05/22 06:00
PMCR- 2013/05/20
CRDT- 2012/04/03 06:00
PHST- 2011/09/22 00:00 [received]
PHST- 2012/02/28 00:00 [revised]
PHST- 2012/03/12 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2013/05/22 06:00 [medline]
PHST- 2013/05/20 00:00 [pmc-release]
AID - S0300-9572(12)00173-6 [pii]
AID - 10.1016/j.resuscitation.2012.03.023 [doi]
PST - ppublish
SO  - Resuscitation. 2012 Aug;83(8):991-5. doi: 10.1016/j.resuscitation.2012.03.023. 
      Epub 2012 Mar 28.