PMID- 22466209
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20181023
IS  - 1539-4794 (Electronic)
IS  - 0146-9592 (Linking)
VI  - 37
IP  - 7
DP  - 2012 Apr 1
TI  - Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the 
      presence of luminal blood.
PG  - 1244-6
LID - 10.1364/OL.37.001244 [doi]
AB  - Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic 
      plaque composition on the basis of the optical absorption contrast between 
      different tissue types. Given the high optical absorption of lipid at 1720 nm 
      wavelength, an atherosclerotic rabbit aorta was imaged at this wavelength ex vivo 
      using an integrated intravascular ultrasound (IVUS) and IVPA imaging catheter in 
      the presence of luminal blood. Strong optical absorption of lipid combined with 
      low background signal from other tissues provides a high-contrast, depth-resolved 
      IVPA image of lipid. The ability to image lipid at a single wavelength without 
      removing luminal blood suggests that in vivo detection of lipid in 
      atherosclerotic plaques using combined IVUS/IVPA imaging is possible.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Biomedical Engineering, University of Texas at Austin, Austin, 
      Texas 78731, USA.
FAU - Karpiouk, Andrei
AU  - Karpiouk A
FAU - Yeager, Doug
AU  - Yeager D
FAU - Amirian, James
AU  - Amirian J
FAU - Litovsky, Silvio
AU  - Litovsky S
FAU - Smalling, Richard
AU  - Smalling R
FAU - Emelianov, Stanislav
AU  - Emelianov S
LA  - eng
GR  - HL096981/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Opt Lett
JT  - Optics letters
JID - 7708433
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - Aorta/diagnostic imaging
MH  - Atherosclerosis/*diagnostic imaging
MH  - Catheterization
MH  - Humans
MH  - Lipids/*analysis
MH  - *Photoacoustic Techniques
MH  - Plaque, Atherosclerotic/*ultrastructure
MH  - Rabbits
MH  - Spectrum Analysis
MH  - *Ultrasonography, Interventional
EDAT- 2012/04/03 06:00
MHDA- 2012/07/25 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 231545 [pii]
AID - 10.1364/OL.37.001244 [doi]
PST - ppublish
SO  - Opt Lett. 2012 Apr 1;37(7):1244-6. doi: 10.1364/OL.37.001244.