PMID- 22466305
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20220316
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 43
IP  - 5
DP  - 2012 Nov
TI  - Central administration of L- and D-aspartate attenuates stress behaviors by 
      social isolation and CRF in neonatal chicks.
PG  - 1969-76
LID - 10.1007/s00726-012-1272-4 [doi]
AB  - Intracerebroventricular (i.c.v.) administration of L-aspartate (L-Asp) attenuates 
      stress responses in neonatal chicks, but the mechanism has not been clarified. In 
      the present study, three behavioral experiments were carried out under socially 
      isolated stressful conditions exacerbated by the use of corticotrophin-releasing 
      factor (CRF). In Experiment 1, i.c.v. injection of L-Asp attenuated behavioral 
      stress responses (distress vocalization and active wakefulness) in a 
      dose-dependent manner. Furthermore, L-Asp increased time spent standing/sitting 
      motionless with eyes open and sitting motionless with head dropped (sleeping 
      posture) in comparison with the group receiving CRF alone. In Experiment 2, 
      i.c.v. injection of D-Asp dose-dependently decreased the number of distress 
      vocalizations and the amount of time spent in active wakefulness. D-Asp increased 
      the time spent standing/sitting motionless with eyes open compared with the group 
      receiving CRF alone. In Experiment 3, we directly compared the effect of L-Asp 
      with that of D-Asp. Both L- and D-Asp induced sedative effects under an acutely 
      stressful condition. However, L-Asp, but not D-Asp, increased the time spent in a 
      sleeping posture. These results indicate that both L- and D-Asp, when present in 
      the brain, could induce a sedative effect, while the mechanism for hypnosis in 
      neonatal chicks may be different for L-Asp in comparison with D-Asp.
FAU - Erwan, Edi
AU  - Erwan E
AD  - Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, 
      Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 
      Fukuoka 812-8581, Japan.
FAU - Tomonaga, Shozo
AU  - Tomonaga S
FAU - Yoshida, Junki
AU  - Yoshida J
FAU - Nagasawa, Mao
AU  - Nagasawa M
FAU - Ogino, Yumi
AU  - Ogino Y
FAU - Denbow, D Michael
AU  - Denbow DM
FAU - Furuse, Mitsuhiro
AU  - Furuse M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120401
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Hypnotics and Sedatives)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
EIN - Amino Acids. 2012 Nov;43(5):1977
MH  - Animals
MH  - Animals, Newborn
MH  - Aspartic Acid/pharmacology/*therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Brain/*drug effects/physiopathology
MH  - Chickens
MH  - *Corticotropin-Releasing Hormone
MH  - D-Aspartic Acid/pharmacology/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Hypnotics and Sedatives/pharmacology/*therapeutic use
MH  - Injections, Intraventricular
MH  - Sleep/drug effects
MH  - Social Isolation
MH  - Stress, Psychological/chemically induced/*drug therapy/physiopathology
MH  - Vocalization, Animal/drug effects
MH  - Wakefulness/drug effects
EDAT- 2012/04/03 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/04/03 06:00
PHST- 2011/10/07 00:00 [received]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - 10.1007/s00726-012-1272-4 [doi]
PST - ppublish
SO  - Amino Acids. 2012 Nov;43(5):1969-76. doi: 10.1007/s00726-012-1272-4. Epub 2012 
      Apr 1.