PMID- 22466837
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 51
IP  - 7
DP  - 2012
TI  - Liver failure caused by light chain deposition disease associated with multiple 
      myeloma.
PG  - 773-6
AB  - Acute liver failure is an unusual complication in multiple myeloma. Here, we 
      report a case of multiple myeloma with light chain deposition disease (LCDD) that 
      presented with progressive jaundice due to intrahepatic cholestasis. Diagnosis 
      was made after liver biopsy that showed deposition of kappa light chains 
      occupying perisinusoidal spaces. The patient developed encephalopathy and liver 
      failure and died despite prompt initiation of dexamethasone therapy. The current 
      prognosis of multiple myeloma patients with liver failure due to LCDD is dismal. 
      New therapeutic strategies might improve this condition.
FAU - Mena-Duran, Armando
AU  - Mena-Duran A
AD  - Hematology Department, La Plana Hospital, Catholic University of Valencia, Spain.
FAU - Munoz Vicente, Elia
AU  - Munoz Vicente E
FAU - Pareja Llorens, Gonzalo
AU  - Pareja Llorens G
FAU - Sanchis Cervera, Jose
AU  - Sanchis Cervera J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120401
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Immunoglobulin kappa-Chains)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cholestasis, Intrahepatic/etiology
MH  - Fatal Outcome
MH  - Hepatic Encephalopathy/etiology
MH  - Humans
MH  - Immunoglobulin kappa-Chains/*metabolism
MH  - Liver Failure, Acute/*etiology/immunology/pathology
MH  - Male
MH  - Multiple Myeloma/*complications/immunology
MH  - Paraproteinemias/complications/immunology
EDAT- 2012/04/03 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - JST.JSTAGE/internalmedicine/51.6510 [pii]
AID - 10.2169/internalmedicine.51.6510 [doi]
PST - ppublish
SO  - Intern Med. 2012;51(7):773-6. doi: 10.2169/internalmedicine.51.6510. Epub 2012 
      Apr 1.