PMID- 22467360
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20221207
IS  - 1099-0496 (Electronic)
IS  - 8755-6863 (Print)
IS  - 1099-0496 (Linking)
VI  - 47
IP  - 11
DP  - 2012 Nov
TI  - Associations of obesity and asthma with functional exercise capacity in urban 
      minority adolescents.
PG  - 1061-9
LID - 10.1002/ppul.22547 [doi]
AB  - PURPOSE: To examine the independent association of asthma and obesity and of 
      their co-existence with functional exercise capacity among urban adolescents. 
      METHODS: One hundred eighteen Hispanic- and African-American adolescents 
      including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese 
      non-asthmatics, and 29 normal-weight non-asthmatics underwent anthropometric 
      measures, 6-minute walk test (6MWT) as measure of functional exercise capacity 
      and spirometry as measure of pulmonary function. The 6-minute walk distance 
      (6MWD) was compared between the four study groups. The association of 6MWD with 
      measures of lower airway obstruction, and measures of adiposity was assessed. 
      RESULTS: The 6MWD was lower among the obese groups with the least distance 
      covered by the obese asthmatic group (P = 0.02). In the obese asthmatic group, 
      there was a negative correlation between 6MWD and body mass index (BMI) (r = 
      -0.35, P = 0.03), but no association was noted with percent-predicted forced 
      expiratory volume in the 1st second (FEV(1) ; r = 0.07, P = 0.70). Conversely, 
      the 6MWD correlated with FEV(1) among normal-weight asthmatics (r = 0.45, P = 
      0.04) and normal-weight non-asthmatics (r = 0.4, P = 0.03), but was not 
      associated with BMI in either of the two groups. After adjusting for age, height, 
      gender, and ethnicity, BMI was noted to be a significant predictor (beta -2.76, 95% 
      CI -4.77 to -0.76, P < 0.01) of the 6MWD among the obese while percent predicted 
      FEV(1) (beta 1.87, 95% CI 0.28-3.45, P = 0.02) was a significant predictor among the 
      normal-weight participants. CONCLUSIONS: Our findings suggest that among urban 
      minority obese asthmatic adolescents, functional exercise capacity was associated 
      with obesity, rather than pulmonary function.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Rastogi, Deepa
AU  - Rastogi D
AD  - Division of Respiratory and Sleep Medicine, Department of Pediatrics, Children's 
      Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, New York 
      10467, USA. drastogi@montefiore.org
FAU - Khan, Unab I
AU  - Khan UI
FAU - Isasi, Carmen R
AU  - Isasi CR
FAU - Coupey, Susan M
AU  - Coupey SM
LA  - eng
GR  - KL2 RR025749/RR/NCRR NIH HHS/United States
GR  - UL1 RR025750/RR/NCRR NIH HHS/United States
GR  - TL1 RR025748/RR/NCRR NIH HHS/United States
GR  - R01 HL102130/HL/NHLBI NIH HHS/United States
GR  - K23 HL105790/HL/NHLBI NIH HHS/United States
GR  - UL1 RR025750-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120329
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
SB  - IM
MH  - Adiposity/physiology
MH  - Adolescent
MH  - Anthropometry
MH  - Asthma/ethnology/*physiopathology
MH  - Black People
MH  - Exercise Test/methods
MH  - Female
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - *Minority Groups
MH  - Obesity/ethnology/*physiopathology
MH  - Physical Endurance/*physiology
MH  - Prevalence
MH  - Respiratory Function Tests
MH  - Urban Population
MH  - Walking/physiology
PMC - PMC3389560
MID - NIHMS361118
COIS- The authors do not have any conflict of interest with the materials included in 
      this manuscript
EDAT- 2012/04/03 06:00
MHDA- 2013/04/16 06:00
PMCR- 2013/11/01
CRDT- 2012/04/03 06:00
PHST- 2011/10/04 00:00 [received]
PHST- 2012/02/23 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - 10.1002/ppul.22547 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2012 Nov;47(11):1061-9. doi: 10.1002/ppul.22547. Epub 2012 Mar 
      29.