PMID- 22467540 OWN - NLM STAT- MEDLINE DCOM- 20120807 LR - 20120402 IS - 1439-7803 (Electronic) IS - 0044-2771 (Linking) VI - 50 IP - 4 DP - 2012 Apr TI - [With the scalpel against the immune system: HIV infection complicated by an unclear colitis]. PG - 382-5 LID - 10.1055/s-0031-1273454 [doi] AB - A 35-year-old Kenian lady with advanced immunodeficiency due to HIV infection started on an antiretroviral therapy. Five months later, a severe colitis was diagnosed, however, no causal pathogen could be found. In order to avoid imminent perforation, a hemicolectomy became necessary, and immediately the symptoms and inflammation markers normalized rapidly. M. tuberculosis could be proven in culture in a draining abdominal lymph node. We assume that the severe inflammation was caused by an immune restoration inflammatory syndrome (IRIS). Essentials in diagnosis, pathogenesis and therapy of IRIS are discussed. CI - (c) Georg Thieme Verlag KG Stuttgart . New York. FAU - Ploch, P AU - Ploch P AD - I. Med. Klinik und Poliklinik, Universitatsmedizin Mainz. FAU - Schimanski, C C AU - Schimanski CC FAU - Goetz, M AU - Goetz M FAU - Orth, C AU - Orth C FAU - Lang, H AU - Lang H FAU - Galle, P R AU - Galle PR FAU - Schuchmann, M AU - Schuchmann M FAU - Kittner, J M AU - Kittner JM LA - ger PT - Case Reports PT - English Abstract PT - Journal Article TT - Mit dem Skalpell gegen das Immunsystem: eine unklare Kolitis bei HIV-Infektion. DEP - 20120401 PL - Germany TA - Z Gastroenterol JT - Zeitschrift fur Gastroenterologie JID - 0033370 SB - IM MH - Adult MH - Colitis/*diagnosis/*therapy MH - Female MH - HIV Infections/*diagnosis/*therapy MH - Humans MH - Immune Reconstitution Inflammatory Syndrome/*diagnosis/*therapy MH - Treatment Outcome EDAT- 2012/04/03 06:00 MHDA- 2012/08/08 06:00 CRDT- 2012/04/03 06:00 PHST- 2012/04/03 06:00 [entrez] PHST- 2012/04/03 06:00 [pubmed] PHST- 2012/08/08 06:00 [medline] AID - 10.1055/s-0031-1273454 [doi] PST - ppublish SO - Z Gastroenterol. 2012 Apr;50(4):382-5. doi: 10.1055/s-0031-1273454. Epub 2012 Apr 1.