PMID- 22467754
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20220409
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 14
IP  - 8
DP  - 2012 Aug
TI  - Left ventricular lead position for cardiac resynchronization: a comprehensive 
      cinegraphic, echocardiographic, clinical, and survival analysis.
PG  - 1139-47
LID - 10.1093/europace/eus045 [doi]
AB  - AIMS: We sought to determine the clinical and survival outcomes of cardiac 
      resynchronization therapy (CRT) associated with left ventricular (LV) lead 
      location. The lateral left ventricle has been considered the optimal LV lead 
      location for CRT. METHODS AND RESULTS: Left ventricular lead cinegrams taken in 
      30 degrees  right and left anterior oblique views were evaluated in 457 recipients of CRT 
      with a pacemaker or a defibrillator from 1 January 2002 to 31 December 2008 in 
      this retrospective study. Left ventricular lead placement was prioritized at 
      implantation into posterolateral (PL), anterolateral (AL), middle cardiac, and 
      anterointerventricular coronary veins. Using echocardiographic LV 16-segment 
      analysis, we grouped the leads as anterior, AL, PL, and posterior locations. New 
      York Heart Association (NYHA) class and echocardiography were assessed before and 
      after CRT. Clinical and survival outcomes after CRT were compared among the four 
      LV lead locations.  Patient baseline demographic characteristics were similar 
      among these four groups. Improvement in NYHA class was significantly greater in 
      the AL (P= 0.04) and PL (P= 0.03) locations than in the anterior location. There 
      was a tendency for greater improvement in LV ejection fraction among the AL (P= 
      0.11) and PL (P= 0.08) locations than the anterior location. Kaplan-Meier 
      survival estimate at 4 years varied for location: AL, 72%; anterior, 48%; PL, 
      62%; and posterior, 72% (P= 0.003). CONCLUSION: Cardiac resynchronization therapy 
      recipients are profiting from all lead positions. However, LV lead placed in the 
      AL and PL positions is more preferential for achieving optimal CRT benefit than 
      leads placed in the anterior position.
FAU - Dong, Ying-Xue
AU  - Dong YX
AD  - Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, 
      MN 55905, USA.
FAU - Powell, Brian D
AU  - Powell BD
FAU - Asirvatham, Samuel J
AU  - Asirvatham SJ
FAU - Friedman, Paul A
AU  - Friedman PA
FAU - Rea, Robert F
AU  - Rea RF
FAU - Webster, Tracy L
AU  - Webster TL
FAU - Brooke, Kelly L
AU  - Brooke KL
FAU - Hodge, David O
AU  - Hodge DO
FAU - Wiste, Heather J
AU  - Wiste HJ
FAU - Yang, Yan-Zong
AU  - Yang YZ
FAU - Hayes, David L
AU  - Hayes DL
FAU - Cha, Yong-Mei
AU  - Cha YM
LA  - eng
PT  - Journal Article
DEP - 20120330
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
CIN - Europace. 2012 Aug;14(8):1076-8. PMID: 22832575
MH  - Aged
MH  - Cardiac Resynchronization Therapy/*methods/mortality
MH  - Echocardiography
MH  - Electrodes, Implanted
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Survival Analysis
EDAT- 2012/04/03 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - eus045 [pii]
AID - 10.1093/europace/eus045 [doi]
PST - ppublish
SO  - Europace. 2012 Aug;14(8):1139-47. doi: 10.1093/europace/eus045. Epub 2012 Mar 30.