PMID- 22468199
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2005-0720 (Electronic)
IS  - 1976-8710 (Print)
IS  - 1976-8710 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Mar
TI  - Open-Label Observational Study for Evaluating the Short-term Benefits of 
      Rabeprazole Medication on Laryngopharyngeal Reflux.
PG  - 28-33
LID - 10.3342/ceo.2012.5.1.28 [doi]
AB  - OBJECTIVES: The aims of this study were to determine the benefits of short-term 
      empirical proton pump inhibitor (PPI) medication on laryngopharyngeal reflux 
      (LPR) and to determine whether scores on the reflux symptom index (RSI) and the 
      reflux finding score (RFS) could be combined to identify subgroups of patients 
      that will more likely to improve with this medication. METHODS: Fifty-one Korean 
      Otolaryngology Board-certified specialists joined this prospective, multi-center, 
      and open-label observational study. A total of 1,142 adult patients with LPR was 
      enrolled for 12 weeks of rabeprazol medication. According to pre-treatment scores 
      on RSI and RFS, patients were divided into 4 subgroups. RFS and RSI were measured 
      repeatedly with a month interval along the treatment period. Changes of RSI and 
      RFS were analyzed in an overall study cohort as well as in each subgroup. 
      RESULTS: Approximately 40% (n=455) of enrolled patients were followed up until 12 
      weeks of PPI treatment. Significant improvement in RSI was obtained in 29%, 58%, 
      and 75% of patients after 4, 8, and 12 weeks of PPI medication. RFS was improved 
      in 16%, 42%, and 57% of the patients with 4, 8, and 12 weeks of PPI medication. 
      All subgroups showed improvement regardless of their pre-treatment scores on the 
      RSI and RFS. CONCLUSION: Even though RSI and RFS may be used as a general 
      guideline for LPR management, pre-treatment RSI and RFS are not useful in 
      predicting the patients' response to short-term PPI medication in the usual 
      pattern of practice for LPR, which is mostly based on the physical evaluation and 
      history taking.
FAU - Shin, Myung-Hee
AU  - Shin MH
AD  - Department of Social & Preventive Medicine, Sungkyunkwan University School of 
      Medicine, Suwon, Korea.
FAU - Nam, Soon Yuhl
AU  - Nam SY
FAU - Park, Young-Hak
AU  - Park YH
FAU - Son, Young-Ik
AU  - Son YI
LA  - eng
PT  - Journal Article
DEP - 20120322
PL  - Korea (South)
TA  - Clin Exp Otorhinolaryngol
JT  - Clinical and experimental otorhinolaryngology
JID - 101474010
PMC - PMC3314802
OTO - NOTNLM
OT  - Laryngopharyngeal reflux
OT  - Predictors of response
OT  - Proton pump inhibitors
OT  - Rabeprazole
OT  - Short-term therapy
COIS- This study was supported partly by a grant from Janssen Korea (RAB-KOR-5034). 
      This was an investigator-initiated study and the company was not involved in 
      writing this manuscript.
EDAT- 2012/04/03 06:00
MHDA- 2012/04/03 06:01
PMCR- 2012/03/01
CRDT- 2012/04/03 06:00
PHST- 2011/09/21 00:00 [received]
PHST- 2011/11/27 00:00 [revised]
PHST- 2011/12/11 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/04/03 06:01 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - 10.3342/ceo.2012.5.1.28 [doi]
PST - ppublish
SO  - Clin Exp Otorhinolaryngol. 2012 Mar;5(1):28-33. doi: 10.3342/ceo.2012.5.1.28. 
      Epub 2012 Mar 22.