PMID- 22468233
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2155-9899 (Print)
IS  - 2155-9899 (Electronic)
VI  - S3
DP  - 2011 Dec 11
TI  - Regulation of Immune Responses by Spontaneous and T cell-mediated Dendritic Cell 
      Death.
LID - 005 [pii]
AB  - In response to antigen stimulations, cells in the immune system undergo dynamic 
      activation, differentiation, expansion and turnover. Programmed cell death is 
      important for maintaining homeostasis of different cell types in the immune 
      system. Dendritic cells (DCs) are a heterogeneous population of antigen 
      presenting cells that capture, process and present antigens to stimulate 
      lymphocytes. DCs have also emerged as major regulators of both innate and 
      adaptive immune responses. Conventional myeloid DCs are relatively short-lived 
      compared to lymphocytes in lymphoid organs. Mitochondrion-dependent apoptosis 
      governed by Bcl-2 family members plays a major role in regulating spontaneous DC 
      turnover. Killing of DCs by antigen-specific T cells also provides a negative 
      feedback mechanism to restrict the duration and the scope of immune responses. 
      Defects in cell death in DCs lead to DC accumulation, resulting in overactivation 
      of lymphocytes and the development of autoimmunity in mice. Programmed cell death 
      in DCs may play essential roles in the regulation of the duration and magnitude 
      of immune responses, and in the protection against autoimmunity and uncontrolled 
      inflammation.
FAU - Chen, Min
AU  - Chen M
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 
      77030, USA.
FAU - Wang, Jin
AU  - Wang J
LA  - eng
GR  - R01 AI074949-05/AI/NIAID NIH HHS/United States
GR  - R01 DK083164-05/DK/NIDDK NIH HHS/United States
GR  - R01 GM087710/GM/NIGMS NIH HHS/United States
GR  - R01 GM087710-08/GM/NIGMS NIH HHS/United States
GR  - R01 DK083164-04/DK/NIDDK NIH HHS/United States
GR  - R21 CA152076/CA/NCI NIH HHS/United States
GR  - R01 GM087710-09/GM/NIGMS NIH HHS/United States
GR  - R21 CA152076-02/CA/NCI NIH HHS/United States
GR  - R01 AI074949/AI/NIAID NIH HHS/United States
GR  - R01 DK083164/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Clin Cell Immunol
JT  - Journal of clinical & cellular immunology
JID - 101563152
PMC - PMC3314292
MID - NIHMS363690
EDAT- 2012/04/03 06:00
MHDA- 2012/04/03 06:01
PMCR- 2012/06/11
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/04/03 06:01 [medline]
PHST- 2012/06/11 00:00 [pmc-release]
AID - 005 [pii]
AID - 10.4172/2155-9899.S3-005 [doi]
PST - ppublish
SO  - J Clin Cell Immunol. 2011 Dec 11;S3:005. doi: 10.4172/2155-9899.S3-005.