PMID- 22468245
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 0973-7707 (Electronic)
IS  - 2231-3796 (Print)
IS  - 2231-3796 (Linking)
VI  - 63
IP  - 2
DP  - 2011 Apr
TI  - A Single Blinded Randomized Controlled Study of the Effect of Conventional Oral 
      Hypoglycemic Agents Versus Intensive Short-Term Insulin Therapy on Pure Tone 
      Audiometry in Type II Diabetes Mellitus.
PG  - 114-8
LID - 10.1007/s12070-011-0132-y [doi]
AB  - Neuropathy is frequently a late complication of diabetes mellitus. Auditory 
      neuropathy and microangiopathy of inner ear are the possible causes of hearing 
      loss in diabetics. To study the correlation between glycaemic control and hearing 
      threshold in patients with type 2 diabetes mellitus and to determine the 
      differences of hearing threshold between groups treated with different modality. 
      This single blind randomized controlled study was performed at the Department of 
      Medicine and Department of Otorhinolaryngology, Hospital Universiti Kebangsaan 
      Malaysia (UKM) between 1st May 2003 and 31st September 2004. This study was 
      approved by Research Ethics Committee (code number FF-137). Subjects were 
      randomized into two groups. Group 1 were patients treated with conventional oral 
      hypoglycemic agents. The patients in group 2 were those treated with insulin 
      injection. The subjects were seen 4 weekly for 3 months. Audiometric test were 
      performed in all subjects at each visit. Blood were taken for fasting blood 
      glucose, Hb1Ac, and fructosamine at every visit to determine the glycaemic 
      controls of the subject. They were 11 patients (22 ears) treated with oral 
      hypoglycemic agents and 17 patients treated (34 ears) with subcutaneous insulin. 
      There is no significant difference between mean pure tone threshold before and 
      after treatment at all frequencies in both groups. There is also no significance 
      different in fasting glucose level and fructosamine. However, there is 
      significant difference HbA1c levels between the two groups after treatment 
      (P < 0.05). This study has shown that glycaemic control does not have significant 
      impact on hearing. The hearing threshold is neither affected by insulin treatment 
      nor by the glycaemic control.
FAU - Asma, A
AU  - Asma A
FAU - Azmi, M Nor
AU  - Azmi MN
FAU - Mazita, A
AU  - Mazita A
FAU - Marina, M B
AU  - Marina MB
FAU - Salina, H
AU  - Salina H
FAU - Norlaila, M
AU  - Norlaila M
LA  - eng
PT  - Journal Article
DEP - 20110208
PL  - India
TA  - Indian J Otolaryngol Head Neck Surg
JT  - Indian journal of otolaryngology and head and neck surgery : official publication 
      of the Association of Otolaryngologists of India
JID - 9422551
PMC - PMC3102159
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Fructosamine
OT  - Glycemic control
OT  - Hearing loss
OT  - Insulin
EDAT- 2012/04/03 06:00
MHDA- 2012/04/03 06:01
PMCR- 2012/04/01
CRDT- 2012/04/03 06:00
PHST- 2010/03/09 00:00 [received]
PHST- 2010/06/13 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/04/03 06:01 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - 132 [pii]
AID - 10.1007/s12070-011-0132-y [doi]
PST - ppublish
SO  - Indian J Otolaryngol Head Neck Surg. 2011 Apr;63(2):114-8. doi: 
      10.1007/s12070-011-0132-y. Epub 2011 Feb 8.