PMID- 22468674
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20181201
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 31
IP  - 7
DP  - 2012 Jul
TI  - DNA interaction studies of a copper (II) complex containing an antiviral drug, 
      valacyclovir: the effect of metal center on the mode of binding.
PG  - 1328-34
LID - 10.1089/dna.2011.1592 [doi]
AB  - The water-soluble complex, [Cu(Val)(2)(NO(3))(2)]; in which Val = valacyclovir, 
      an antiviral drug, has been synthesized and characterized by elemental analysis, 
      furier transfer-infrared, hydrogen nuclear magnetic resonance (H NMR), and UV-Vis 
      techniques. The binding of this Cu (II) complex to calf thymus DNA was 
      investigated using fluorimetry, spectrophotometry, circular dichroism, and 
      viscosimetry. In fluorimetric studies, the enthalpy and entropy of the reaction 
      between the complex and calf-thymus DNA (CT-DNA) showed that the reaction is 
      endothermic (DeltaH = 208.22 kJ mol(-1); DeltaS = 851.35 J mol(-1)K(-1)). The complex 
      showed the absorption hyperchromism in its ultra violet-visible (UV-Vis) spectrum 
      with DNA. The calculated binding constant, K(b), obtained from UV-Vis absorption 
      studies was 2 x 10(5) M(-1). Moreover, the complex induced detectable changes in 
      the circular dichroism spectrum of CT-DNA, as well as changes in its viscosity. 
      The results suggest that this copper (II) complex interacts with CT-DNA via a 
      groove-binding mode.
FAU - Shahabadi, Nahid
AU  - Shahabadi N
AD  - Department of Chemistry, Faculty of Science, Razi University, Kermanshah, Iran. 
      nahidshahabadi@yahoo.com
FAU - Fatahi, Parvin
AU  - Fatahi P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120402
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (Antiviral Agents)
RN  - 0 (Organometallic Compounds)
RN  - 789U1901C5 (Copper)
RN  - 9007-49-2 (DNA)
RN  - HG18B9YRS7 (Valine)
RN  - MZ1IW7Q79D (Valacyclovir)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/*analogs & derivatives/chemistry
MH  - Animals
MH  - Antiviral Agents/*chemistry
MH  - Binding Sites
MH  - Cattle
MH  - Copper/*chemistry
MH  - DNA/*metabolism
MH  - Organometallic Compounds/*chemistry/*metabolism
MH  - Spectrum Analysis
MH  - Structure-Activity Relationship
MH  - Valacyclovir
MH  - Valine/*analogs & derivatives/chemistry
MH  - Viscosity
EDAT- 2012/04/04 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/04/04 06:00
PHST- 2012/04/04 06:00 [entrez]
PHST- 2012/04/04 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1089/dna.2011.1592 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2012 Jul;31(7):1328-34. doi: 10.1089/dna.2011.1592. Epub 2012 Apr 
      2.