PMID- 22469482
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20220331
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 14
IP  - 5
DP  - 2012 May
TI  - Musosal tumour necrosis factor alpha in diverticular disease of the colon is 
      overexpressed with disease severity.
PG  - e258-63
LID - 10.1111/j.1463-1318.2012.02926.x [doi]
AB  - AIM: Inflammation occurs in diverticular disease (DD), but there is little 
      information on inflammatory cytokines such as tumour necrosis factor alpha (TNF-alpha). 
      The aim of this study was to assess TNF-alpha expression in DD and to see whether it 
      is related to the severity of the disease. METHOD: Twenty-four patients with 
      symptomatic DD were divided into those with acute uncomplicated diverticulitis 
      (AUD) (12 patients) and those with symptomatic uncomplicated diverticular disease 
      (SUDD) (12 patients). Twelve further patients with asymptomatic diverticulosis 
      (AD), six with segmental colitis associated with diverticulosis (SCAD), with 
      ulcerative colitis (UC) and six healthy individuals (HC) were enrolled as 
      controls. TNF-alpha expression in the colonic mucosa was assessed by the amount of 
      mRNA codifying for the synthesis of TNF-alpha. RESULTS: TNF-alpha expression was 
      significantly higher in AUD than in HC (P=0.0007), in AD (P=0.0001) and in SUDD 
      (P=0.0179). It was significantly higher also in SUDD than in HC (P=0.0007) and in 
      AD (P=0.0001). TNF-alpha expression in AUD did not differ significantly from that in 
      UC (P=0.0678) and SCAD (P=0.0610). It was significantly higher in UC, SCAD and 
      AUD than in SUDD (P=0.0007, P=0.0001, P=0.0179). CONCLUSION: TNF-alpha expression in 
      DD seems to be related to the severity of the disease. In particular, it appears 
      to be overexpressed in DD with inflammation (AUD and SUDD) compared with DD 
      without (AD).
CI  - (c) 2012 The Authors. Colorectal Disease (c) 2012 The Association of Coloproctology 
      of Great Britain and Ireland.
FAU - Tursi, A
AU  - Tursi A
AD  - Servizio di Gastroenterologia Territoriale, ASL BAT, Andria BT, Italy. 
      antotursi@tiscali.it
FAU - Elisei, W
AU  - Elisei W
FAU - Brandimarte, G
AU  - Brandimarte G
FAU - Giorgetti, G M
AU  - Giorgetti GM
FAU - Inchingolo, C D
AU  - Inchingolo CD
FAU - Nenna, R
AU  - Nenna R
FAU - Picchio, M
AU  - Picchio M
FAU - Giorgio, F
AU  - Giorgio F
FAU - Ierardi, E
AU  - Ierardi E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of 
      Great Britain and Ireland
JID - 100883611
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Colitis, Ulcerative/metabolism/pathology
MH  - Diverticulitis, Colonic/*metabolism/pathology
MH  - Diverticulosis, Colonic/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Intestinal Mucosa/*metabolism/pathology
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/metabolism
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2012/04/04 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/04/04 06:00
PHST- 2012/04/04 06:00 [entrez]
PHST- 2012/04/04 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - 10.1111/j.1463-1318.2012.02926.x [doi]
PST - ppublish
SO  - Colorectal Dis. 2012 May;14(5):e258-63. doi: 10.1111/j.1463-1318.2012.02926.x.