PMID- 22469627
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20131121
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 231
IP  - 1
DP  - 2012 May 16
TI  - Biperiden (M(1) antagonist) impairs the expression of cocaine conditioned place 
      preference but potentiates the expression of cocaine-induced behavioral 
      sensitization.
PG  - 213-6
LID - 10.1016/j.bbr.2012.03.030 [doi]
AB  - Cocaine addiction is a public health issue in many countries, stressing the need 
      for more effective treatments. As all drugs of abuse, cocaine acts on the brain 
      reward system, increasing dopamine (DA) levels. Other neurotransmitters such as 
      acetylcholine (ACh) are involved in the mechanisms underlying the development and 
      the maintenance of cocaine addiction. ACh plays an important role in learning and 
      memory processes and also regulates DA in some specific regions of the central 
      nervous system. The present study investigated the effects of biperiden, a 
      muscarinic cholinergic (mACh) antagonist in two animal models: conditioned place 
      preference (CPP) and behavioral sensitization. Male C57BL/6J mice were used in 
      both studies. The CPP protocol was unbiased and carried out in three phases: 
      habituation, conditioning and testing. For conditioning, cocaine was injected at 
      a dose of 10mg/kg in eight 15 min-sessions. The treatment with biperiden (doses 
      of 0.1, 1 and 10 mg/kg) was made 30 min prior to the testing session. For 
      behavioral sensitization development, cocaine was administered at the dose of 10 
      mg/kg for 10 days. After sensitization, two challenges were performed: saline and 
      cocaine (5 mg/kg). Biperiden (10 mg/kg) was administered 30 min before the 
      cocaine challenge. At the dose of 10 mg/kg, biperiden blocked the cocaine-CPP 
      expression, suggesting an effect on conditioned memory retrieval. However, the 
      same dose potentiated the expression of behavioral sensitization, suggesting an 
      increase in DA release, probably in the NAc. Biperiden, as other mACh 
      antagonists, may be a promising drug for the pharmacologic treatment of cocaine 
      addiction.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Ramos, Anna C
AU  - Ramos AC
AD  - Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Andersen, Monica L
AU  - Andersen ML
FAU - Oliveira, Maria G M
AU  - Oliveira MG
FAU - Soeiro, Aline C
AU  - Soeiro AC
FAU - Galduroz, Jose C F
AU  - Galduroz JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120326
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Receptor, Muscarinic M1)
RN  - 0FRP6G56LD (Biperiden)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Association Learning/drug effects
MH  - Behavior, Animal/drug effects
MH  - Biperiden/*pharmacology
MH  - Cocaine/*pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Male
MH  - Mice
MH  - Muscarinic Antagonists/*pharmacology
MH  - Receptor, Muscarinic M1/*antagonists & inhibitors
EDAT- 2012/04/04 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/04/04 06:00
PHST- 2012/02/16 00:00 [received]
PHST- 2012/03/12 00:00 [revised]
PHST- 2012/03/16 00:00 [accepted]
PHST- 2012/04/04 06:00 [entrez]
PHST- 2012/04/04 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S0166-4328(12)00225-2 [pii]
AID - 10.1016/j.bbr.2012.03.030 [doi]
PST - ppublish
SO  - Behav Brain Res. 2012 May 16;231(1):213-6. doi: 10.1016/j.bbr.2012.03.030. Epub 
      2012 Mar 26.