PMID- 22471437
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20120404
IS  - 1521-0758 (Electronic)
IS  - 0191-3123 (Linking)
VI  - 36
IP  - 2
DP  - 2012 Apr
TI  - Light-chain deposition disease of the kidney: a case report.
PG  - 134-8
LID - 10.3109/01913123.2011.642464 [doi]
AB  - A 41-year-old man was admitted for evaluation of nephrotic syndrome associated 
      with microhematuria, hypertension, and moderate renal failure. In serum and urine 
      samples, monoclonal IgG-lambda was detected. Bone marrow examination showed 
      normal representation of all cell lines with normal range of plasma cells. Renal 
      biopsy demonstrated diabetes-like nodular glomerulosclerosis. Immunofluorescence 
      failed to demonstrate the presence of kappa or lambda light chains in the kidney. 
      Electron microcopy showed granular electron-dense deposits along the glomerular 
      basement membranes and in the mesangial nodules. The patient was diagnosed as 
      having light-chain deposition disease (LCDD) without evidence of plasma cell 
      dyscrasia. This report was designed to stress the significant challenges that 
      remain in the diagnosis of LCDD-related glomerulopathy. The salient morphological 
      features that help in making an accurate diagnosis are discussed.
FAU - Darouich, Sihem
AU  - Darouich S
AD  - Electron Microscopy Laboratory, Faculty of Medicine of Tunis, Tunis, Tunisia.
FAU - Goucha, Rym
AU  - Goucha R
FAU - Jaafoura, Mohamed Habib
AU  - Jaafoura MH
FAU - Zekri, Semy
AU  - Zekri S
FAU - Kheder, Adel
AU  - Kheder A
FAU - Maiz, Hedi Ben
AU  - Maiz HB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Ultrastruct Pathol
JT  - Ultrastructural pathology
JID - 8002867
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoglobulin Light Chains/*immunology
MH  - Kidney/*pathology/*ultrastructure
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Nephrotic Syndrome/immunology/*pathology
EDAT- 2012/04/05 06:00
MHDA- 2012/08/10 06:00
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2012/04/05 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.3109/01913123.2011.642464 [doi]
PST - ppublish
SO  - Ultrastruct Pathol. 2012 Apr;36(2):134-8. doi: 10.3109/01913123.2011.642464.