PMID- 22472775
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Print)
IS  - 1933-0219 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Jul
TI  - CD8alpha(+)beta(-) and CD8alpha(+)beta(+) plasmacytoid dendritic cells induce Foxp3(+) regulatory T cells 
      and prevent the induction of airway hyper-reactivity.
PG  - 432-43
LID - 10.1038/mi.2012.20 [doi]
AB  - Dendritic cells (DCs) control the balance between protection against pathogens 
      and tolerance to innocuous or self-antigens. Here, we demonstrate for the first 
      time that mouse plasmacytoid DCs (pDCs) can be segregated into three distinct 
      populations, exhibiting phenotypic and functional differences, according to their 
      surface expression of CD8alpha or CD8beta as CD8alpha(-)beta(-), CD8alpha(+)beta(-), or CD8alpha(+)beta(+). In a mouse 
      model of lung inflammation, adoptive transfer of CD8alpha(+)beta(-) or CD8alpha(+)beta(+) pDCs prevents 
      the development of airway hyper-reactivity. The tolerogenic features of these 
      subsets are associated with increased production of retinoic acid, which leads to 
      the enhanced induction of Foxp3(+) regulatory T cells compared with CD8alpha(-)beta(-) pDCs. 
      Our data thus identify subsets of pDCs with potent tolerogenic functions that may 
      contribute to the maintenance of tolerance in mucosal sites such as the lungs.
FAU - Lombardi, V
AU  - Lombardi V
AD  - Department of Molecular Microbiology and Immunology, Keck School of Medicine, 
      University of Southern California, Los Angeles, California, USA.
FAU - Speak, A O
AU  - Speak AO
FAU - Kerzerho, J
AU  - Kerzerho J
FAU - Szely, N
AU  - Szely N
FAU - Akbari, O
AU  - Akbari O
LA  - eng
GR  - R01 AI066020/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120404
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
SB  - IM
CIN - Mucosal Immunol. 2014 Jan;7(1):200-1. PMID: 24192911
CIN - Mucosal Immunol. 2014 Sep;7(5):1278-9. PMID: 24938747
MH  - Adoptive Transfer
MH  - Aldehyde Dehydrogenase/metabolism
MH  - Animals
MH  - Antigens/immunology/metabolism
MH  - CD8 Antigens/*metabolism
MH  - Cell Differentiation/immunology
MH  - Cells, Cultured
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/*immunology/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Forkhead Transcription Factors/*metabolism
MH  - Immune Tolerance/immunology
MH  - Immunity, Mucosal
MH  - Inflammation/immunology/prevention & control
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Transgenic
MH  - Respiratory Hypersensitivity/*immunology/prevention & control
MH  - T-Lymphocytes, Regulatory/cytology/*immunology/metabolism
PMC - PMC3378819
MID - NIHMS372910
COIS- DISCLOSURE The authors have no conflicting financial interests.
EDAT- 2012/04/05 06:00
MHDA- 2012/10/17 06:00
PMCR- 2013/01/01
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2012/04/05 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S1933-0219(22)01321-6 [pii]
AID - 10.1038/mi.2012.20 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2012 Jul;5(4):432-43. doi: 10.1038/mi.2012.20. Epub 2012 Apr 4.