PMID- 22473041
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20161125
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Sep
TI  - Differentiation of optic disc edema from optic nerve head drusen with 
      spectral-domain optical coherence tomography.
PG  - 207-11
LID - 10.1097/WNO.0b013e318252561b [doi]
AB  - BACKGROUND: To assess the efficacy of quantitative analysis of the optic nerve 
      head and peripapillary retinal nerve fiber layer (RNFL) with the spectral-domain 
      optical coherence tomography (SD-OCT) in differentiating optic disc edema (ODE) 
      from optic nerve head drusen (ONHD). METHODS: Prospective clinical study. 
      Twenty-five eyes of 25 ODE patients (group 1), 25 eyes of 25 ONHD patients (group 
      2), and 25 eyes of 25 healthy subjects were included. The thickness of the 
      peripapillary RNFL, the thickness of the subretinal hyporeflective space (SHYPS), 
      the area of the SHYPS, the horizontal length of the optic nerve head, and the 
      angle between the temporal RNFL and the optic nerve head (alpha-angle) were evaluated 
      with SD-OCT. RESULTS: The mean RNFL thickness was significantly greater in group 
      1 when compared with group 2 and control group (P < 0.001). The receiver 
      operating characteristic curve areas for temporal and nasal RNFL thicknesses in 
      differentiating group 1 and group 2 were 0.819 and 0.851, respectively (for 
      temporal RNFL thickness >101.5 mum: sensitivity 92%, specificity 65%; for nasal 
      RNFL thickness >74.5 mum: sensitivity 92%, specificity 47%). The mean SHYPS 
      thickness, SHYPS area, and degree of the alpha-angle were greater in group 1 when 
      compared with group 2 (P < 0.05). For the SHYPS thickness >464 mum: 85% 
      sensitivity and 60% specificity; for the SHYPS area >811 mum: 85% sensitivity and 
      89% specificity; and for the alpha-angle >141 degrees : 77% sensitivity and 95% specificity 
      were obtained. CONCLUSION: The quantitative analysis of the optic nerve head and 
      peripapillary RNFL with SD-OCT can provide useful data in differentiating ODE 
      from ONHD.
FAU - Sarac, Ozge
AU  - Sarac O
AD  - Yildirim Beyazit University, Ataturk Hospital, Ankara, Turkey. 
      osarac2002@yahoo.com
FAU - Tasci, Yelda Y
AU  - Tasci YY
FAU - Gurdal, Canan
AU  - Gurdal C
FAU - Can, Izzet
AU  - Can I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
CIN - J Neuroophthalmol. 2013 Jun;33(2):204-5. PMID: 23584154
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*diagnostic imaging/pathology
MH  - Optic Disk/*diagnostic imaging
MH  - Optic Disk Drusen/*complications
MH  - Papilledema/*etiology
MH  - ROC Curve
MH  - Radiography
MH  - Retina/pathology
MH  - Spectrum Analysis
MH  - *Tomography, Optical Coherence
MH  - Young Adult
EDAT- 2012/04/05 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2012/04/05 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1097/WNO.0b013e318252561b [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2012 Sep;32(3):207-11. doi: 10.1097/WNO.0b013e318252561b.