PMID- 22473371
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20220408
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 129
IP  - 5
DP  - 2012 May
TI  - Obese Mexican American children have elevated MCP-1, TNF-alpha, monocyte 
      concentration, and dyslipidemia.
PG  - e1180-6
LID - 10.1542/peds.2011-2477 [doi]
AB  - BACKGROUND AND OBJECTIVE: Obesity is an independent risk factor for chronic 
      disease. The prevalence of obesity is especially high among Mexican American 
      children. Peripheral blood monocytes are altered with obesity contributing to 
      elevated systemic inflammation and increased risk of chronic disease. In 
      addition, obesity alters the circulating levels of cytokines/chemokines that 
      influence monocyte behavior. The study objective was to investigate alterations 
      in blood monocytes and plasma cytokines/chemokine levels among healthy weight 
      (standardized BMI [zBMI] </=85th percentile; n = 66), overweight (zBMI 85th-95th 
      percentile; n = 23), and obese (zBMI >/=95th percentile; n = 39) Mexican American 
      children. METHODS: Blood samples were analyzed for total and subset monocyte 
      concentration via flow cytometry. Serum monocyte chemoattractant protein-1 
      (MCP-1), fractalkine, interleukin-8, and tumor necrosis factor alpha (TNF-alpha) were 
      measured by using a Milliplex MagPix assay. Serum cholesterol, high-density 
      lipoproteins, triglycerides, and glucose were measured by using an enzymatic 
      assay. RESULTS: Total monocyte concentration (P = .012), classic monocyte 
      concentration (P = .045), MCP-1 (P = .015), and TNF-alpha (P = .002) were 
      significantly greater in obese children compared with healthy weight children. 
      Also, overweight and obese children had elevated triglycerides (P = .001) and 
      reduced high-density lipoproteins (P = .033) compared with healthy weight 
      children. CONCLUSIONS: Childhood obesity alters monocytes and circulating 
      chemokines, putting children at a greater risk of developing obesity-related 
      chronic diseases in adulthood. Further characterization of early immune 
      alterations in childhood obesity may provide additional clinical insight into the 
      assessment of obesity-related disease risk.
FAU - Breslin, Whitney L
AU  - Breslin WL
AD  - Laboratory of Integrated Physiology, University of Houston, Houston, Texas 
      77004-6016, USA.
FAU - Johnston, Craig A
AU  - Johnston CA
FAU - Strohacker, Kelley
AU  - Strohacker K
FAU - Carpenter, Katie C
AU  - Carpenter KC
FAU - Davidson, Tiffany R
AU  - Davidson TR
FAU - Moreno, Jennette P
AU  - Moreno JP
FAU - Foreyt, John P
AU  - Foreyt JP
FAU - McFarlin, Brian K
AU  - McFarlin BK
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120402
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/ethnology/immunology
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cross-Sectional Studies
MH  - Dyslipidemias/epidemiology/*ethnology/*immunology
MH  - Female
MH  - Humans
MH  - Inflammation/ethnology/immunology
MH  - *Leukocyte Count
MH  - Male
MH  - *Mexican Americans/statistics & numerical data
MH  - *Monocytes
MH  - Obesity/epidemiology/*ethnology/*immunology
MH  - Reference Standards
MH  - Reference Values
MH  - Risk Factors
MH  - Texas
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2012/04/05 06:00
MHDA- 2012/06/22 06:00
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2012/04/05 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - peds.2011-2477 [pii]
AID - 10.1542/peds.2011-2477 [doi]
PST - ppublish
SO  - Pediatrics. 2012 May;129(5):e1180-6. doi: 10.1542/peds.2011-2477. Epub 2012 Apr 
      2.