PMID- 22474435
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Print)
IS  - 1687-6121 (Linking)
VI  - 2012
DP  - 2012
TI  - Gastric carcinomas localized to the cardia.
PG  - 457831
LID - 10.1155/2012/457831 [doi]
LID - 457831
AB  - Objectives. Gastric adenocarcinomas localized to the cardia are increasing. 
      Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in 
      hypergastrinemia, and the use of proton pump inhibitors (PPI) leading to 
      hypergastrinemia has increased considerably during the last decades. We have 
      examined cardia cancers for neuroendocrine and ECL cell differentiation. Methods. 
      Thirty-two cardia cancers were examined by immunohistochemical labelling of 
      chromogranin A (CgA), synaptophysin, serotonin, and histidine decarboxylase 
      (HDC). Information about PPI use was collected from the patient records. Results. 
      In 15 of 32 tumours, there were positive signs for one or several neuroendocrine 
      markers. Five cases were CgA and serotonin positive; three of these carcinomas 
      were also positive for HDC. Three patients were long-term users of PPI, and two 
      of these were immunoreactive for neuroendocrine markers. Conclusions. A high 
      proportion of cardia cancers expressed neuroendocrine markers, but only few 
      patients with cardia cancers were using PPI.
FAU - Bakkelund, Karin E
AU  - Bakkelund KE
AD  - Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, 
      7006 Trondheim, Norway.
FAU - Nordrum, Ivar S
AU  - Nordrum IS
FAU - Fossmark, Reidar
AU  - Fossmark R
FAU - Waldum, Helge L
AU  - Waldum HL
LA  - eng
PT  - Journal Article
DEP - 20120228
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC3299334
EDAT- 2012/04/05 06:00
MHDA- 2012/04/05 06:01
PMCR- 2012/02/28
CRDT- 2012/04/05 06:00
PHST- 2011/10/04 00:00 [received]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2012/04/05 06:00 [entrez]
PHST- 2012/04/05 06:00 [pubmed]
PHST- 2012/04/05 06:01 [medline]
PHST- 2012/02/28 00:00 [pmc-release]
AID - 10.1155/2012/457831 [doi]
PST - ppublish
SO  - Gastroenterol Res Pract. 2012;2012:457831. doi: 10.1155/2012/457831. Epub 2012 
      Feb 28.