PMID- 22475522
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20220317
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 500
IP  - 1
DP  - 2012 May 25
TI  - Association of RAGE gene polymorphisms with type 2 diabetes mellitus, diabetic 
      retinopathy and diabetic nephropathy.
PG  - 1-9
LID - 10.1016/j.gene.2012.03.056 [doi]
AB  - A meta-analysis was performed to assess the associations of the receptor for 
      advanced glycation end products (RAGE) gene polymorphisms [Gly82Ser (rs2070600), 
      1704G/T (rs184003), 429T/C (rs1800625)] with type 2 diabetes mellitus (T2DM), 
      diabetic retinopathy (DR) and diabetic nephropathy (DN). A comprehensive research 
      was conducted to identify all case-control or cohort studies. The fixed or random 
      effect pooled measure was selected based on the homogeneity test among studies 
      that was evaluated with I(2). Meta-regression was used to explore the potential 
      sources of between-study heterogeneity. Publication bias was estimated using 
      Peters test. Twenty-nine articles were included. Overall, after excluding 
      articles deviating from Hardy-Weinberg equilibrium in controls and sensitive 
      analysis, no significant association was found between RAGE gene polymorphisms 
      (Gly82Ser, 1704G/T, 429T/C) and any of T2DM, DR and DN risk, respectively. 
      Subgroup analysis stratified by ethnicity (Asian and Caucasian) also found no 
      significant association between the above-mentioned three polymorphisms and T2DM 
      risk, respectively. This meta-analysis suggested that there might be no 
      association of RAGE gene polymorphisms (Gly82Ser, 1704G/T, 429T/C) with T2DM, DR 
      and DN risk.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Kang, Peipei
AU  - Kang P
AD  - Department of Epidemiology and Health Statistics, Shandong University, People's 
      Republic of China.
FAU - Tian, Changwei
AU  - Tian C
FAU - Jia, Chongqi
AU  - Jia C
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120323
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Amino Acid Substitution
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Diabetic Nephropathies/ethnology/*genetics
MH  - Diabetic Retinopathy/ethnology/*genetics
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*genetics
EDAT- 2012/04/06 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/04/06 06:00
PHST- 2011/11/04 00:00 [received]
PHST- 2012/03/15 00:00 [revised]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2012/04/06 06:00 [entrez]
PHST- 2012/04/06 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S0378-1119(12)00368-X [pii]
AID - 10.1016/j.gene.2012.03.056 [doi]
PST - ppublish
SO  - Gene. 2012 May 25;500(1):1-9. doi: 10.1016/j.gene.2012.03.056. Epub 2012 Mar 23.