PMID- 22476561
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20211021
IS  - 1420-908X (Electronic)
IS  - 1023-3830 (Linking)
VI  - 61
IP  - 6
DP  - 2012 Jun
TI  - Promoter -2518 single nucleotide polymorphism of monocyte chemoattractant 
      protein-1 is associated with clinical severity in Behcet's disease.
PG  - 541-5
LID - 10.1007/s00011-012-0471-5 [doi]
AB  - OBJECTIVE: We investigated whether promoter -2518 single nucleotide polymorphism 
      (SNP) of the monocyte chemoattractant protein-1 (MCP-1) gene contributes to 
      susceptibility and clinical features or severity in Behcet's disease (BD) 
      patients. METHODS: One hundred and thirty-two BD patients and 113 healthy 
      subjects, matched by sex and age, were enrolled. Promoter -2518 polymorphism of 
      the MCP-1 gene was analyzed using automated sequencing. Clinical severity in BD 
      patients was classified into mild, moderate, and severe features and assessed by 
      total severity scores. Clinical features and severity was also compared according 
      to genotypes using either the chi-squared or Fisher's exact test and Mann-Whitney 
      test, as indicated. RESULTS: There were no significant differences in alleles (G 
      allele vs. A allele, p=0.845) and genotypes with -2518 SNP (GG vs. GA vs. AA, 
      p=0.916) between BD patients and controls. No clinical features were associated 
      with genotypes with -2518 polymorphism of MCP-1. However, the frequency of either 
      GA or AA genotype in patients with moderate lesions and moderate to severe 
      lesions was significantly increased compared with that in patients with the GG 
      genotype (p=0.044 and p=0.038, respectively). Total severity scores in the AA 
      genotype were higher than those in the GG and GA genotypes (p=0.039 and p=0.003, 
      respectively). Moreover, patients with either the GA or AA genotype had higher 
      scores than those with the GG genotype (p=0.041). CONCLUSIONS: This study 
      demonstrated that genotypes with A allele with -2518 polymorphism of the MCP-1 
      gene might have increased risk of severity of clinical features, but not 
      susceptibility to BD.
FAU - Kim, Seong-Kyu
AU  - Kim SK
AD  - Department of Internal Medicine, Arthritis and Autoimmunity Research Centre, 
      Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
FAU - Jang, Won-Cheoul
AU  - Jang WC
FAU - Ahn, Young-Chang
AU  - Ahn YC
FAU - Lee, Sang-Hyun
AU  - Lee SH
FAU - Lee, Shin-Seok
AU  - Lee SS
FAU - Hur, Jin-Wuk
AU  - Hur JW
LA  - eng
PT  - Journal Article
DEP - 20120403
PL  - Switzerland
TA  - Inflamm Res
JT  - Inflammation research : official journal of the European Histamine Research 
      Society ... [et al.]
JID - 9508160
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*genetics/pathology
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Severity of Illness Index
EDAT- 2012/04/06 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/04/06 06:00
PHST- 2011/12/22 00:00 [received]
PHST- 2012/03/16 00:00 [accepted]
PHST- 2012/04/06 06:00 [entrez]
PHST- 2012/04/06 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - 10.1007/s00011-012-0471-5 [doi]
PST - ppublish
SO  - Inflamm Res. 2012 Jun;61(6):541-5. doi: 10.1007/s00011-012-0471-5. Epub 2012 Apr 
      3.