PMID- 22476595
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20220409
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Linking)
VI  - 162
IP  - 3-4
DP  - 2012 Feb
TI  - Individualised PPI prescription in patients on combination antiplatelet therapy 
      and upper gastrointestinal events after percutaneous coronary intervention: a 
      cohort study.
PG  - 67-73
LID - 10.1007/s10354-012-0056-5 [doi]
AB  - BACKGROUND: We investigated the effect of individualised proton pump inhibitors 
      (PPI) prescription on upper gastrointestinal adverse events in a cohort of 
      patients who received combination antiplatelet therapy (aspirin and clopidogrel) 
      after percutaneous coronary intervention (PCI). METHODS: Upper gastrointestinal 
      risk factors and other parameters were extracted from a dedicated electronic 
      database. Patients were contacted with a standardised questionnaire. A structured 
      phone interview was performed in all patients with upper gastrointestinal adverse 
      events. RESULTS: A cohort of 718 patients on combination therapy yielded 87 
      (12.1%) patients with prophylactic PPI treatment. Upper gastrointestinal adverse 
      events occurred in 18.4% patients with and in 11.1% patients without prophylactic 
      PPI (OR 1.80, P = 0.054). Co-treatment with corticosteroids was the main 
      identifiable risk factor for upper gastrointestinal adverse events (adjusted OR 
      5.45, P = 0.014). CONCLUSIONS: Individualised prescription of PPI-prophylaxis 
      after PCI in patients on combined antiplatelet therapy based on risk assessment 
      for upper gastrointestinal bleeding seems to represent an effective measure to 
      minimise upper gastrointestinal adverse events after PCI.
FAU - Hauptle, Rahel
AU  - Hauptle R
AD  - University of Zurich, Zurich, Switzerland. rahel.haeuptle@yahoo.de
FAU - Weilenmann, Daniel
AU  - Weilenmann D
FAU - Schneider, Tino
AU  - Schneider T
FAU - Haile, Sarah R
AU  - Haile SR
FAU - Ammann, Peter
AU  - Ammann P
FAU - Knellwolf, Christina
AU  - Knellwolf C
FAU - Borovicka, Jan
AU  - Borovicka J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acute Coronary Syndrome/diagnostic imaging/*therapy
MH  - Adrenal Cortex Hormones/administration & dosage/adverse effects
MH  - Adverse Drug Reaction Reporting Systems
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - Aspirin/administration & dosage/*adverse effects
MH  - Clopidogrel
MH  - Cohort Studies
MH  - Combined Modality Therapy
MH  - Coronary Angiography
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gastrointestinal Hemorrhage/*chemically induced/*prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*therapy
MH  - Peptic Ulcer/*chemically induced/*prevention & control
MH  - Platelet Aggregation Inhibitors/administration & dosage/*adverse effects
MH  - *Precision Medicine
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects
MH  - Ticlopidine/administration & dosage/adverse effects/*analogs & derivatives
EDAT- 2012/04/06 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/04/06 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2012/01/02 00:00 [accepted]
PHST- 2012/04/06 06:00 [entrez]
PHST- 2012/04/06 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1007/s10354-012-0056-5 [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2012 Feb;162(3-4):67-73. doi: 10.1007/s10354-012-0056-5.