PMID- 22477643
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20211021
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 47
IP  - 3
DP  - 2012 Jul
TI  - Association between BDNF Val66Met polymorphism and cognitive performance in 
      antipsychotic-naive patients with schizophrenia.
PG  - 505-10
LID - 10.1007/s12031-012-9750-4 [doi]
AB  - Cognitive impairment is one of the core symptoms in schizophrenia, which reflects 
      the neurodevelopmental deficits in the etiology of this disease. Brain-derived 
      neurotrophic factor (BDNF) plays an important role in various neurodevelopmental 
      processes. Growing evidence has shown that BDNF may be involved in the etiology 
      of schizophrenia. The aim of this study was to examine the association of the 
      BDNF Val66Met polymorphism with cognition in patients with schizophrenia. Various 
      neuropsychological tests including the Wechsler Adult Intelligence Scale-Revised, 
      the Wechsler Memory Scale-Revised, and the Wisconsin Card Sorting Test (WCST) 
      were employed in a sample of 112 antipsychotic-naive patients with schizophrenia 
      and 63 healthy controls. We examined the Val66Met polymorphism in the 112 
      patients and 394 controls. Among the patients, cognition was compared between Met 
      allele carriers and non-Met allele carriers. A wide range of cognitive deficits 
      were demonstrated in the schizophrenic patients, compared with the controls 
      (Ps < 0.01). No significant differences of genotype or allele distribution were 
      identified between patients and controls. The patients with Met allele showed 
      more percent WCST perseverative errors than those without Met allele (P = 0.007). 
      After stratification based on gender, an association between the Met allele and a 
      higher percentage of perseverative errors was found in male patients (P = 0.014), 
      but not in females (P = 0.09). Cognitive performance is broadly impaired in 
      schizophrenic patients. The BDNF Val66Met polymorphism may be involved in the 
      impaired executive function. This effect may have gender-specific 
      characteristics.
FAU - Lu, Weihong
AU  - Lu W
AD  - Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200030, People's Republic of China.
FAU - Zhang, Chen
AU  - Zhang C
FAU - Yi, Zhenghui
AU  - Yi Z
FAU - Li, Zezhi
AU  - Li Z
FAU - Wu, Zhiguo
AU  - Wu Z
FAU - Fang, Yiru
AU  - Fang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120403
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Psychotic Disorders/*genetics/physiopathology
MH  - Schizophrenia/*genetics/*physiopathology
MH  - Young Adult
EDAT- 2012/04/06 06:00
MHDA- 2013/04/12 06:00
CRDT- 2012/04/06 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/03/08 00:00 [accepted]
PHST- 2012/04/06 06:00 [entrez]
PHST- 2012/04/06 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
AID - 10.1007/s12031-012-9750-4 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2012 Jul;47(3):505-10. doi: 10.1007/s12031-012-9750-4. Epub 2012 
      Apr 3.