PMID- 22479582
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20240317
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 3
DP  - 2012
TI  - Lower blood calcium associates with unfavorable prognosis and predicts for bone 
      metastasis in NSCLC.
PG  - e34264
LID - 10.1371/journal.pone.0034264 [doi]
LID - e34264
AB  - Ionized calcium was involved in various cellular signal pathways,and regulates 
      many cellular processes, including those relevant to tumorigenesis. We hypothesis 
      that imbalance of calcium homeostasis is correlated with development of lung 
      carcinomas. We collected the clinical data of 1084 patients with non small cell 
      lung cancer (NSCLC) treated in Shandong Provincial Hospital, Shandong University. 
      Logistic regression was used to determine the association between calcium levels 
      and clinical characteristics, and COX regression and Kaplan-Meier model were 
      applied to analyze risk factors on overall survival. Blood electrolytes were 
      tested before treatment; and nearly 16% patients with NSCLC were complained with 
      decreased blood calcium, which is more frequent than that in other electrolytes. 
      Further, Multivariate logistic regression analysis disclosed that there were 
      significant correlation between blood calcium decrease and moderate and poor 
      differentiation (P = 0.012, OR = 1.926 (1.203-4.219)), squamous cell carcinoma 
      (P = 0.024, OR = 1.968(1.094-3.540)), and bone metastasis (P = 0.032, 
      OR = 0.396(0.235-0.669)). In multivariate COX regression analysis, advanced lymph 
      node stage and decreased blood calcium were significantly and independent, 
      unfavorable prognostic factors (P<0.001). Finally, the Kaplan-Meier Survival 
      curve revealed that blood calcium decrease was associated with shorter survival 
      (Log-rank; chi(2) = 26.172,P<0.001). Our finding indicates that lower blood calcium 
      levels are associated with a higher risk of unfavorable prognosis and bone 
      metastasis of NSCLC.
FAU - Shen, Hongchang
AU  - Shen H
AD  - Bio-bank Center, Provincial Hospital Affiliated to Shandong University, Shandong 
      University, Jinan, People's Republic of China.
FAU - Li, Yongqiu
AU  - Li Y
FAU - Liao, Yida
AU  - Liao Y
FAU - Zhang, Tiehong
AU  - Zhang T
FAU - Liu, Qi
AU  - Liu Q
FAU - Du, Jiajun
AU  - Du J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120330
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Electrolytes)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aged
MH  - Bone Neoplasms/*blood/mortality/*secondary
MH  - Calcium/*blood
MH  - Carcinoma, Non-Small-Cell Lung/*blood/mortality/*pathology
MH  - Electrolytes/metabolism
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*blood/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Multivariate Analysis
MH  - Neoplasm Metastasis/*diagnosis
MH  - Odds Ratio
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Risk Factors
PMC - PMC3316630
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/04/06 06:00
MHDA- 2012/11/06 06:00
PMCR- 2012/03/30
CRDT- 2012/04/06 06:00
PHST- 2011/11/06 00:00 [received]
PHST- 2012/02/24 00:00 [accepted]
PHST- 2012/04/06 06:00 [entrez]
PHST- 2012/04/06 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
PHST- 2012/03/30 00:00 [pmc-release]
AID - PONE-D-11-22305 [pii]
AID - 10.1371/journal.pone.0034264 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(3):e34264. doi: 10.1371/journal.pone.0034264. Epub 2012 Mar 30.