PMID- 22481913
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220318
IS  - 1687-4765 (Electronic)
IS  - 1687-4757 (Print)
VI  - 2012
DP  - 2012
TI  - PPARgamma and Oxidative Stress: Con(beta) Catenating NRF2 and FOXO.
PG  - 641087
LID - 10.1155/2012/641087 [doi]
LID - 641087
AB  - Peroxisome-proliferator activator receptor gamma (PPARgamma) is a nuclear receptor of 
      central importance in energy homeostasis and inflammation. Recent experimental 
      pieces of evidence demonstrate that PPARgamma is implicated in the oxidative stress 
      response, an imbalance between antithetic prooxidation and antioxidation forces 
      that may lead the cell to apoptotic or necrotic death. In this delicate and 
      intricate game of equilibrium, PPARgamma stands out as a central player devoted to 
      the quenching and containment of the damage and to foster cell survival. However, 
      PPARgamma does not act alone: indeed the nuclear receptor is at the point of 
      interconnection of various pathways, such as the nuclear factor erythroid 
      2-related factor 2 (NRF2), Wnt/beta-catenin, and forkhead box proteins O (FOXO) 
      pathways. Here we reviewed the role of PPARgamma in response to oxidative stress and 
      its interaction with other signaling pathways implicated in this process, an 
      interaction that emerged as a potential new therapeutic target for several 
      oxidative-related diseases.
FAU - Polvani, Simone
AU  - Polvani S
AD  - Gastroenterology Unit, Department of Clinical Pathophysiology, University of 
      Florence, Viale Pieraccini 6, 50139 Firenze, Italy.
FAU - Tarocchi, Mirko
AU  - Tarocchi M
FAU - Galli, Andrea
AU  - Galli A
LA  - eng
PT  - Journal Article
DEP - 20120305
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC3317010
EDAT- 2012/04/07 06:00
MHDA- 2012/04/07 06:01
PMCR- 2012/03/05
CRDT- 2012/04/07 06:00
PHST- 2011/09/01 00:00 [received]
PHST- 2011/11/05 00:00 [revised]
PHST- 2011/11/17 00:00 [accepted]
PHST- 2012/04/07 06:00 [entrez]
PHST- 2012/04/07 06:00 [pubmed]
PHST- 2012/04/07 06:01 [medline]
PHST- 2012/03/05 00:00 [pmc-release]
AID - 10.1155/2012/641087 [doi]
PST - ppublish
SO  - PPAR Res. 2012;2012:641087. doi: 10.1155/2012/641087. Epub 2012 Mar 5.