PMID- 22484094
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20161125
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 222
IP  - 2
DP  - 2012 Jun
TI  - Asymmetric dimethylarginine in adults with cystathionine beta-synthase deficiency.
PG  - 509-11
LID - 10.1016/j.atherosclerosis.2012.03.009 [doi]
AB  - In hyperhomocysteinemia (HHcy), an independent risk factor for cardiovascular 
      diseases, endothelial dysfunction due to reduced bioavailability of nitric oxide 
      is a consistent finding. However, the underlying mechanisms remain unknown. 
      Increased levels of the nitric oxide synthase inhibitor asymmetric 
      dimethylarginine (ADMA) have been associated with HHcy, and may contribute, at 
      least in part, for the homocysteine-induced endothelial dysfunction, but whether 
      cystathionine beta-synthase (CBS) deficiency is associated with increased ADMA has 
      hardly been investigated. To address this question, we measured total 
      homocysteine (tHcy), ADMA and symmetric dimethylarginine (SDMA) in plasma of 22 
      adult CBS deficient patients, using established HPLC techniques. Results showed 
      that in CBS deficient patients with elevated levels of tHcy (median (total 
      range): 33 (14-237) mumol/L), both ADMA and SDMA levels were normal. Moreover, 
      tHcy and ADMA concentrations were not correlated (r(s)=0.017, p=0.94). Our 
      results favor the hypothesis that the negative vascular effects of HHcy have an 
      ADMA-independent etiology.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Rocha, Monica S
AU  - Rocha MS
AD  - Department of Clinical Chemistry, Metabolic Unit, Institute for Cardiovascular 
      Research (ICAR-VU), VU University Medical Center, Amsterdam, The Netherlands.
FAU - Teerlink, Tom
AU  - Teerlink T
FAU - Janssen, Mirian C H
AU  - Janssen MC
FAU - Kluijtmans, Leo A J
AU  - Kluijtmans LA
FAU - Smulders, Yvo
AU  - Smulders Y
FAU - Jakobs, Cornelis
AU  - Jakobs C
FAU - Tavares de Almeida, Isabel
AU  - Tavares de Almeida I
FAU - Rivera, Isabel
AU  - Rivera I
FAU - Castro, Rita
AU  - Castro R
FAU - Blom, Henk J
AU  - Blom HJ
LA  - eng
PT  - Journal Article
DEP - 20120324
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 49787G1ULV (symmetric dimethylarginine)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Arginine/*analogs & derivatives/blood
MH  - Biomarkers/blood
MH  - Chromatography, High Pressure Liquid
MH  - Endothelium, Vascular/metabolism/physiopathology
MH  - Homocysteine/blood
MH  - Homocystinuria/*blood/physiopathology
MH  - Humans
EDAT- 2012/04/10 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/04/10 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/03/05 00:00 [revised]
PHST- 2012/03/08 00:00 [accepted]
PHST- 2012/04/10 06:00 [entrez]
PHST- 2012/04/10 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - S0021-9150(12)00193-1 [pii]
AID - 10.1016/j.atherosclerosis.2012.03.009 [doi]
PST - ppublish
SO  - Atherosclerosis. 2012 Jun;222(2):509-11. doi: 
      10.1016/j.atherosclerosis.2012.03.009. Epub 2012 Mar 24.