PMID- 2248424
OWN - NLM
STAT- MEDLINE
DCOM- 19910107
LR  - 20131121
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 41
IP  - 11 Pt 2
DP  - 1990 Nov
TI  - Pilot study of nicardipine for acute ischemic stroke.
PG  - 1017-22
AB  - The author performed a pilot study of nicardipine (NC), a Ca(+)+ channel blocker, 
      to study its dosing, toxicity, and possible efficacy for hemispheric cerebral 
      infarction within 12 hours (mean 6.9 hr) of onset to determine the advisability 
      of proceeding with a multi-centered controlled trial. NC was administered IV (3 
      to 7 mg/hr) X 72 hours by titrating dose to mean arterial blood pressure (MABP 
      not less than 10% of baseline), then orally X 30 days. Forty-three patients have 
      been entered; mean age 63 (range 34-89), 25 male and 18 female. Only 3 had CT 
      evidence of infarct on entry. Results have shown improvement in a 100-point (pt) 
      graded exam (40 pts at entry, 68 pts at 3 months). Of 20 patients completing 3 
      months' evaluation, 17 improved and none worsened. Sixteen out of 20 were at home 
      and 8 had minimal or no impairment. Mean Barthel's index was 72. Mean maximal 
      serum NC level was 75 ng/mL. MABP decreased from 103 (entry) to 83 (72 hours). A 
      larger controlled study is warranted to determine the efficacy of NC for acute 
      cerebral infarct.
FAU - Rosenbaum, D M
AU  - Rosenbaum DM
AD  - Department of Neurology, University of Texas Medical School, Houston.
FAU - Grotta, J C
AU  - Grotta JC
FAU - Yatsu, F M
AU  - Yatsu FM
FAU - Picone, C M
AU  - Picone CM
FAU - Pettigrew, L C
AU  - Pettigrew LC
FAU - Bratina, P
AU  - Bratina P
FAU - Zabramski, J
AU  - Zabramski J
FAU - Spetzler, R
AU  - Spetzler R
FAU - Lopez, L
AU  - Lopez L
FAU - Marler, J
AU  - Marler J
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - CZ5312222S (Nicardipine)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/drug effects/physiology
MH  - Brain Ischemia/*drug therapy/mortality/physiopathology
MH  - Dose-Response Relationship, Drug
MH  - Drug Evaluation
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Nicardipine/adverse effects/blood/*therapeutic use
MH  - Pilot Projects
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - Angiology. 1990 Nov;41(11 Pt 2):1017-22.