PMID- 22484564
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20120509
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 106
IP  - 4
DP  - 2012 Jun 25
TI  - Macronutrient-induced differences in food intake relate with hepatic oxidative 
      metabolism and hypothalamic regulatory neuropeptides in rainbow trout 
      (Oncorhynchus mykiss).
PG  - 499-505
LID - 10.1016/j.physbeh.2012.03.027 [doi]
AB  - This study examines how dietary macronutrient-induced changes in voluntary food 
      intake (FI) relate to changes in markers of hepatic oxidative metabolism and in 
      the expression of FI regulatory neuropeptides in a teleost model, the rainbow 
      trout. Rainbow trout were fed for 6weeks with one of four iso-energetic diets 
      (2x2 factorial design), containing either a high (HP, ~500 g.kg(-1) DM) or a low 
      (LP, ~250 g.kg(-1) DM) protein level (PL) with, at each PL, fat (diets HP-F and 
      LP-F) being substituted by an iso-energetic amount of gelatinized corn starch 
      (diets HP-St and LP-St) as non-protein energy source (ES). Irrespective of the 
      dietary PL, FI (g.kg(-0.8).d(-1)) and digestible energy intake (DEI, 
      kJ.kg(-0.8).d(-1)) were significantly (P<0.05) reduced by the iso-energetic 
      replacement of fat by starch as non-protein ES. Interestingly, trout fed these 
      St-diets had higher gene expression of markers of hepatic oxidative 
      phosphorylation (OxPhos), i.e., ubiquinol-cytochrome c reductase subunit 2 (UCR2) 
      and cytochrome oxidase subunit 4 (COX4) and of aerobic oxidative capacity (CS, 
      citrate synthase), which paralleled glucokinase (GK) transcription. This positive 
      relation suggests that glucose phosphorylation and markers of mitochondrial 
      OxPhos are linked at the hepatic level and possibly triggered the observed 
      reduction in FI. Moreover, trout displaying the reduced FI had higher cocaine 
      amphetamine regulator transcript (CART) mRNA in hypothalamus, whereas 
      neuropeptide Y (NPY) mRNA did not follow the macronutrient-induced changes in FI. 
      Further studies are needed to unravel the mechanisms by which diet-induced 
      changes in hepatic metabolism inform central feeding centers involved in the 
      regulation of FI in fish.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Figueiredo-Silva, A Claudia
AU  - Figueiredo-Silva AC
AD  - INRA, UR1067 Nutrition Metabolism Aquaculture, F-64310 Saint Pee-sur-Nivelle, 
      France.
FAU - Saravanan, Subramanian
AU  - Saravanan S
FAU - Schrama, Johan W
AU  - Schrama JW
FAU - Kaushik, Sadasivam
AU  - Kaushik S
FAU - Geurden, Inge
AU  - Geurden I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120329
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Dietary Fats)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Neuropeptides)
RN  - 0 (RNA, Messenger)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein)
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - Animals
MH  - Body Composition/physiology
MH  - Diet
MH  - Dietary Fats/pharmacology
MH  - Eating/*physiology
MH  - Energy Intake/physiology
MH  - Energy Metabolism/physiology
MH  - Gene Expression/drug effects
MH  - Growth/physiology
MH  - Homeostasis/physiology
MH  - Hypothalamus/*physiology
MH  - Liver/enzymology/*metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuropeptide Y/metabolism
MH  - Neuropeptides/*physiology
MH  - Oncorhynchus mykiss/*physiology
MH  - Oxidation-Reduction
MH  - Oxidative Phosphorylation/drug effects
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Starch/pharmacology
EDAT- 2012/04/10 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/04/10 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/03/08 00:00 [revised]
PHST- 2012/03/22 00:00 [accepted]
PHST- 2012/04/10 06:00 [entrez]
PHST- 2012/04/10 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - S0031-9384(12)00132-1 [pii]
AID - 10.1016/j.physbeh.2012.03.027 [doi]
PST - ppublish
SO  - Physiol Behav. 2012 Jun 25;106(4):499-505. doi: 10.1016/j.physbeh.2012.03.027. 
      Epub 2012 Mar 29.