PMID- 22486506
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20220309
IS  - 1365-2052 (Electronic)
IS  - 0268-9146 (Linking)
VI  - 43
IP  - 3
DP  - 2012 Jun
TI  - Identifying putative candidate genes and pathways involved in immune responses to 
      porcine reproductive and respiratory syndrome virus (PRRSV) infection.
PG  - 328-32
LID - 10.1111/j.1365-2052.2011.02251.x [doi]
AB  - Differences in gene expression were compared between RNAs from lungs of high (HR) 
      and low (LR) porcine reproductive and respiratory syndrome virus (PRRSV) burden 
      pigs using the swine protein-annotated long oligonucleotide microarray, the 
      Pigoligoarray. Pathway analyses were carried out to determine biological 
      processes, pathways and networks that differ between the LR and HR responses. 
      Differences existed between HR and LR pigs for 16 signalling pathways [P < 
      0.01/-log (P-value) >1.96]. Top canonical pathways included acute phase response 
      signalling, crosstalk between dendritic cells and natural killer cells and tight 
      junction signalling, with numerous immune response genes that were upregulated 
      (SOCS1, SOD2, RBP4, HLA-B, HLA-G, PPP2R1A and TAP1) or downregulated (IL18, TF, 
      C4BPA, C1QA, C1QB and TYROBP). One mechanism, regulation of complement 
      activation, may have been blocked in HR (PRRSV-susceptible) pigs and could 
      account for the poor clearance of PRRSV by infected macrophages. Multiple 
      inhibiting signals may have prevented effective immune responses in susceptible 
      HR pigs, although some protective genes were upregulated in these pigs. It is 
      likely that in HR pigs, expression of genes associated with protection was 
      delayed, so that the immune response was not stimulated early; thus, PRRSV 
      infection prevented protective immune responses.
CI  - (c) 2011 USDA ARS, Animal Genetics (c) 2011 Stichting International Foundation for 
      Animal Genetics.
FAU - Wysocki, M
AU  - Wysocki M
AD  - Animal Parasitic Diseases Laboratory, ANRI, ARS, USDA, BARC-East, Beltsville, MD 
      20705, USA.
FAU - Chen, H
AU  - Chen H
FAU - Steibel, J P
AU  - Steibel JP
FAU - Kuhar, D
AU  - Kuhar D
FAU - Petry, D
AU  - Petry D
FAU - Bates, J
AU  - Bates J
FAU - Johnson, R
AU  - Johnson R
FAU - Ernst, C W
AU  - Ernst CW
FAU - Lunney, J K
AU  - Lunney JK
LA  - eng
SI  - GEO/GSE25120
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110919
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
SB  - IM
MH  - Animals
MH  - Bronchi/metabolism/pathology/virology
MH  - Gene Expression Profiling/veterinary
MH  - *Gene Expression Regulation
MH  - Genetic Variation
MH  - Lung/metabolism/pathology/virology
MH  - Lymph Nodes/metabolism/pathology/virology
MH  - Oligonucleotide Array Sequence Analysis/veterinary
MH  - Polymerase Chain Reaction
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/*immunology/virology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Swine
EDAT- 2012/04/11 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/04/11 06:00
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - 10.1111/j.1365-2052.2011.02251.x [doi]
PST - ppublish
SO  - Anim Genet. 2012 Jun;43(3):328-32. doi: 10.1111/j.1365-2052.2011.02251.x. Epub 
      2011 Sep 19.