PMID- 22487171
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20220309
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 35
IP  - 9
DP  - 2012 May
TI  - Noradrenaline-induced enhancement of oscillatory local field potentials in the 
      mouse accessory olfactory bulb does not depend on disinhibition of mitral cells.
PG  - 1433-45
LID - 10.1111/j.1460-9568.2012.08070.x [doi]
AB  - The olfactory bulb differs from other brain regions by its use of bidirectional 
      synaptic transmission at dendrodendritic reciprocal synapses. These reciprocal 
      synapses provide tight coupling of inhibitory feedback from granule cell 
      interneurons to mitral cell projection neurons in the accessory olfactory bulb 
      (AOB), at the first stage of vomeronasal processing. It has been proposed that 
      both the mGluR2 agonist DCG-IV and noradrenaline promote mate recognition memory 
      formation by reducing GABAergic feedback on mitral cells. The resultant mitral 
      cell disinhibition is thought to induce a long-lasting enhancement in the gain of 
      inhibitory feedback from granule to mitral cells, which selectively gates the 
      transmission of the learned chemosensory information. However, we found that 
      local infusions of both noradrenaline and DCG-IV failed to disinhibit AOB neural 
      activity in urethane-anaesthetised mice. DCG-IV infusion had similar effects to 
      the GABA(A) agonist isoguvacine, suggesting that it increased GABAergic 
      inhibition in the AOB rather than reducing it. Noradrenaline infusion into the 
      AOB also failed to disinhibit mitral cells in awake mice despite inducing 
      long-term increases in power of AOB local field potentials, similar to those 
      observed following memory formation. These results suggest that mitral cell 
      disinhibition is not essential for the neural changes in the AOB that underlie 
      mate recognition memory formation in mice.
CI  - (c) 2012 The Authors. European Journal of Neuroscience (c) 2012 Federation of 
      European Neuroscience Societies and Blackwell Publishing Ltd.
FAU - Leszkowicz, Emilia
AU  - Leszkowicz E
AD  - School of Physiology and Pharmacology, University of Bristol, Medical Sciences 
      Building, University Walk, Bristol BS8 1TD, UK.
FAU - Khan, Selina
AU  - Khan S
FAU - Ng, Stephanie
AU  - Ng S
FAU - Ved, Nikita
AU  - Ved N
FAU - Swallow, Daniel L
AU  - Swallow DL
FAU - Brennan, Peter A
AU  - Brennan PA
LA  - eng
GR  - BB/E020283/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - BB ⁄ E020283 ⁄ 1/BB_/Biotechnology and Biological Sciences Research 
      Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120404
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Cyclopropanes)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (GABA Agonists)
RN  - 0 (Isonicotinic Acids)
RN  - 147782-19-2 (2-(2,3-dicarboxycyclopropyl)glycine)
RN  - 3IN71E75Z5 (Urethane)
RN  - TE7660XO1C (Glycine)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YTF580771Y (isoguvacine)
SB  - IM
MH  - Anesthetics, Intravenous
MH  - Animals
MH  - Brain Waves/*drug effects
MH  - Cyclopropanes/pharmacology
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Female
MH  - GABA Agonists/pharmacology
MH  - Glycine/analogs & derivatives/pharmacology
MH  - Isonicotinic Acids/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microdialysis
MH  - Neurons/*drug effects/*physiology
MH  - Norepinephrine/*pharmacology
MH  - Olfactory Bulb/*cytology/*physiology
MH  - Urethane/pharmacology
MH  - Wakefulness
EDAT- 2012/04/11 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/04/11 06:00
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1111/j.1460-9568.2012.08070.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2012 May;35(9):1433-45. doi: 10.1111/j.1460-9568.2012.08070.x. 
      Epub 2012 Apr 4.