PMID- 22487278
OWN - NLM
STAT- MEDLINE
DCOM- 20120817
LR  - 20120410
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - Inflammatory cell patterns in the nasal mucosa of patients with idiopathic 
      rhinitis.
PG  - e55-62
LID - 10.2500/ajra.2012.26.3725 [doi]
AB  - BACKGROUND: Nonallergic rhinitis comprises many subgroups of rhinitis (vasomotor 
      rhinitis, nonallergic rhinitis with eosinophilia syndrome, occupational rhinitis, 
      idiopathic rhinitis, etc. in which its main feature is known to be free of 
      allergy. We evaluate the cellular infiltrate of subjects with idiopathic rhinitis 
      and compare them with allergic and control counterparts for detecting underlying 
      pathophysiology. METHODS: Subjects selected from patients admitted to Istanbul 
      University Medical Faculty between 2006 and 2009 were classified into idiopathic 
      rhinitis (n = 16; mean age, 26.5 years), allergic rhinitis (n = 17; mean age, 
      31.1 years), and the control (n = 25, mean age, 28.8 years) groups. Inferior 
      turbinate specimens were collected using Gerritsma forceps. Skin-prick testing 
      was performed. Immunohistochemical detection was performed using B7 (chymase, 
      clone CC1) and G3 (tryptase, clone AA1) primary antibodies for mast cells, human 
      eosinophil major basic protein (clone BMK-13) for eosinophils, and immunoglobulin 
      E (IgE) Ab-1 for mast and plasma cells in epithelium, superficial, and deep 
      submucosa. RESULTS: We found significantly higher levels of mast cells within the 
      different sites of nasal mucosa of allergic and idiopathic subjects compared with 
      normal mucosa (p < 0.05). Additionally, a significant increase was observed in 
      IgE(+) cells of the patients with allergic and idiopathic rhinitis compared with 
      the controls (p < 0.05 for each) Eosinophils were significantly increased within 
      the epithelium of allergic patients' mucosa. CONCLUSION: We seem to have 
      supportive data about possible mechanisms of "idiopathic rhinitis" that suggests 
      local allergic inflammation. The study results provided important information for 
      further provocation and immunohistochemical studies analyzing the shared 
      mechanism of allergic and idiopathic rhinitis.
FAU - Comoglu, Senol
AU  - Comoglu S
AD  - Ear, Nose, and Throat Department, Istanbul Faculty of Medicine, Istanbul 
      University, Capa-Istanbul, Turkey. drcomoglu@hotmail.com
FAU - Keles, Nesil
AU  - Keles N
FAU - Deger, Kemal
AU  - Deger K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Major Basic Protein)
RN  - EC 3.4.21.39 (Chymases)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Adult
MH  - Chymases/metabolism
MH  - Eosinophil Major Basic Protein/metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Mast Cells/metabolism/pathology
MH  - Nasal Mucosa/immunology/*pathology
MH  - Plasma Cells/metabolism/pathology
MH  - Rhinitis/etiology/immunology/*pathology
MH  - Skin Tests
MH  - Tryptases/metabolism
MH  - Turbinates/pathology
EDAT- 2012/04/11 06:00
MHDA- 2012/08/18 06:00
CRDT- 2012/04/11 06:00
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2012/08/18 06:00 [medline]
AID - 10.2500/ajra.2012.26.3725 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2012 Mar-Apr;26(2):e55-62. doi: 10.2500/ajra.2012.26.3725.