PMID- 22487771
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jul
TI  - Differences in the locomotor-activating effects of indirect serotonin agonists in 
      habituated and non-habituated rats.
PG  - 88-94
LID - 10.1016/j.pbb.2012.03.023 [doi]
AB  - The indirect serotonin (5-HT) agonist 3,4-methylenedioxymethamphetamine (MDMA) 
      produces a distinct behavioral profile in rats consisting of locomotor 
      hyperactivity, thigmotaxis, and decreased exploration. The indirect 5-HT agonist 
      alpha-ethyltryptamine (AET) produces a similar behavioral profile. Using the 
      Behavioral Pattern Monitor (BPM), the present investigation examined whether the 
      effects of MDMA and AET are dependent on the novelty of the testing environment. 
      These experiments were conducted in Sprague-Dawley rats housed on a reversed 
      light cycle and tested during the dark phase of the light/dark cycle. We found 
      that racemic MDMA (RS-MDMA; 3 mg/kg, SC) increased locomotor activity in rats 
      tested in novel BPM chambers, but had no effect on locomotor activity in rats 
      habituated to the BPM chambers immediately prior to testing. Likewise, AET (5 
      mg/kg, SC) increased locomotor activity in non-habituated animals but not in 
      animals habituated to the test chambers. These results were unexpected because 
      previous reports indicate that MDMA has robust locomotor-activating effects in 
      habituated animals. To further examine the influence of habituation on 
      MDMA-induced locomotor activity, we conducted parametric studies with S-(+)-MDMA 
      (the more active enantiomer) in habituated and non-habituated rats housed on a 
      standard or reversed light cycle. Light cycle was included as a variable due to 
      reported differences in sensitivity to serotonergic ligands during the dark and 
      light phases. In confirmation of our initial studies, rats tested during the dark 
      phase and habituated to the BPM did not show an S-(+)-MDMA (3 mg/kg, SC)-induced 
      increase in locomotor activity, whereas non-habituated rats did. By contrast, in 
      rats tested during the light phase, S-(+)-MDMA increased locomotor activity in 
      both non-habituated and habituated rats, although the response in habituated 
      animals was attenuated. The finding that habituation and light cycle interact to 
      influence MDMA- and AET-induced hyperactivity demonstrates that there are 
      previously unrecognized complexities associated with the behavioral effects of 
      these drugs.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Halberstadt, Adam L
AU  - Halberstadt AL
AD  - Department of Psychiatry, University of California San Diego, La Jolla, CA 
      92093-0804, USA.
FAU - Buell, Mahalah R
AU  - Buell MR
FAU - Price, Diana L
AU  - Price DL
FAU - Geyer, Mark A
AU  - Geyer MA
LA  - eng
GR  - F32 DA025412/DA/NIDA NIH HHS/United States
GR  - F32 DA025412-03/DA/NIDA NIH HHS/United States
GR  - R01 DA002925/DA/NIDA NIH HHS/United States
GR  - R01 DA002925-29/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120331
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Serotonin Receptor Agonists)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Habituation, Psychophysiologic/*drug effects/physiology
MH  - Male
MH  - Motor Activity/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Receptor Agonists/*pharmacology
PMC - PMC3354037
MID - NIHMS367863
EDAT- 2012/04/11 06:00
MHDA- 2013/03/15 06:00
PMCR- 2013/07/01
CRDT- 2012/04/11 06:00
PHST- 2011/11/14 00:00 [received]
PHST- 2012/03/05 00:00 [revised]
PHST- 2012/03/24 00:00 [accepted]
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - S0091-3057(12)00094-9 [pii]
AID - 10.1016/j.pbb.2012.03.023 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2012 Jul;102(1):88-94. doi: 10.1016/j.pbb.2012.03.023. 
      Epub 2012 Mar 31.