PMID- 22487823
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20120410
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 29
IP  - 2
DP  - 2012 Apr
TI  - [Association study of brain-derived neurotrophic factor Val66Met polymorphism and 
      clinical characteristics of first episode schizophrenia].
PG  - 155-8
LID - 10.3760/cma.j.issn.1003-9406.2012.02.008 [doi]
AB  - OBJECTIVE: To assess the association between brain-derived neurotrophic factor 
      (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode 
      schizophrenia in a Chinese Han population. METHODS: Genotyping of BDNF Val66Met 
      polymorphism was carried out for 135 schizophrenic patients and 483 healthy 
      controls with TaqMan probe technology. The patients' psychotic symptoms were 
      assessed using the positive and negative syndrome scale (PANSS). RESULTS: A 
      significant difference was found in genotype distribution and allelic frequency 
      of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met 
      homozygotes had a significantly higher score in anxiety/depression factor, 
      cognitive factor and total score of PANSS than Val carriers. CONCLUSION: BDNF 
      gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. 
      The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms 
      in first episode schizophrenia patients.
FAU - Sun, Meng-meng
AU  - Sun MM
AD  - School of Medicine, Shandong University, Jinan, Shandong, People's Republic of 
      China.
FAU - Liu, Lan-fen
AU  - Liu LF
FAU - Yang, Li-min
AU  - Yang LM
FAU - Wang, Yan
AU  - Wang Y
FAU - Cui, Kai-yan
AU  - Cui KY
FAU - Wang, Li-na
AU  - Wang LN
FAU - Li, Cui-luan
AU  - Li CL
FAU - Qiao, Dong-dong
AU  - Qiao DD
FAU - Wang, Ru-zhan
AU  - Wang RZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Schizophrenia/*genetics
MH  - Young Adult
EDAT- 2012/04/11 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/04/11 06:00
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - 940629038 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2012.02.008 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Apr;29(2):155-8. doi: 
      10.3760/cma.j.issn.1003-9406.2012.02.008.