PMID- 22487840
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 29
IP  - 2
DP  - 2012 Apr
TI  - [Analysis of HLA-A, B, and DRB1 polymorphism and genetic distance in Han 
      population living in Yantai and Weihai regions of Shandong province].
PG  - 229-33
LID - 10.3760/cma.j.issn.1003-9406.2012.02.024 [doi]
AB  - OBJECTIVE: To investigate allelic and haplotypic polymorphisms of human leukocyte 
      antigen(HLA) genes at A, B and DRB1 loci in Yantai and Weihai Han population and 
      analyze the genetic relationship between Yantai, Weihai Han population and other 
      populations. METHODS: A total of 4062 unrelated Han ethnic individual from Yantai 
      and Weihai regions were genotyped by polymerase chain reaction-sequence specific 
      olignucleotide probe(PCR-SSOP) for HLA-A, B and DRB1 loci. Allelic and haplotypic 
      frequencies were estimated by maximum likelihood estimation method using Arlequin 
      3.5 software. Genetic distances were computed, and phylogenetic tree was 
      constructed using Mega5.0 software. RESULTS: Respectively 18, 33 and 13 alleles 
      were observed at HLA-A, B and DRB1 loci. The most frequent alleles were 
      HLA-A*02(0.2935), HLA-B*15(0.1485) and HLA-DRB1*15(0.1621). And the most common 
      three loci haplotype was A*30-B*13-DRB1*07(0.0649). A*33-B*58, A*66-DRB1*13 and 
      B*08-DRB1*03 showed the strongest linkage disequilibrium. Yantai and Weihai Han 
      population has the shortest genetic distance with Jilin Han population (0.0034). 
      CONCLUSION: The HLA-A, B and DRB1 loci are highly polymorphic in Han population 
      from Yantai and Weihai, and this population has closest relationship with Han 
      population from Jilin province.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan, Shandong, People's 
      Republic of China
FAU - Zhuang, Yun-long
AU  - Zhuang YL
FAU - Nie, Xiang-min
AU  - Nie XM
FAU - Liu, Yan
AU  - Liu Y
FAU - Song, Yong-hong
AU  - Song YH
FAU - Wang, Guang-chen
AU  - Wang GC
FAU - Zhu, Chuan-fu
AU  - Zhu CF
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Asian People/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Phylogeny
MH  - Polymorphism, Genetic
EDAT- 2012/04/11 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/04/11 06:00
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - 940629054 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2012.02.024 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Apr;29(2):229-33. doi: 
      10.3760/cma.j.issn.1003-9406.2012.02.024.