PMID- 22489263
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1948-5182 (Electronic)
IS  - 1948-5182 (Print)
VI  - 4
IP  - 3
DP  - 2012 Mar 27
TI  - Relationship between interleukin 18 polymorphisms and susceptibility to chronic 
      hepatitis B virus infection.
PG  - 105-9
LID - 10.4254/wjh.v4.i3.105 [doi]
AB  - AIM: To identify the relationship between the tagging single nucleotide 
      polymorphism sites (tagSNPs) of the Interleukin-18 (IL-18) gene and genetic 
      susceptibility to chronic hepatitis B virus infection in Chinese patients. 
      METHODS: Five hundred and one cases of chronic hepatitis B virus (HBV) infection 
      and 301 HBV natural clearance controls were studied. Two tagSNPs in the IL-18 
      gene (rs1946518A/C and rs574424C/G) were genotyped by the Multiplex Snapshot 
      technique. The genotype and allele frequencies were calculated and analyzed. 
      RESULTS: In the genotypes of rs1946518, the AA type was present at a higher 
      frequency in the patients compared to those in the controls. Odds ratio (OR) of 
      the AA genotype for the comparison with that of the AC and the CC genotype was 
      1.537 (95% confidence intervals (CI): 1.116-2.218, P = 0.009 < 0.025). In 
      phenotypes, the allele C at rs1946518 was of a significantly lower frequency in 
      the patients with chronic hepatitis B than that in the controls (P = 0.017 < 
      0.025). OR of the allele A for the comparison with that of the allele C was 1.279 
      (95% CI: 1.045-1.567). As for the rs574424 genotypes, no significant difference 
      in this genotype distribution or in this allele frequency between the patients 
      and the control subjects was observed. No significant difference in the haplotype 
      frequencies between the patients with chronic hepatitis B and HBV natural 
      clearance individuals was displayed. CONCLUSION: The data suggest that genotype 
      AA and the allele A of the IL-18 at position rs1946518 are closely associated 
      with the resistance to chronic hepatitis B and may be the dangerous gene. 
      However, no statistical association was found between polymorphisms of rs574424 
      for IL-18 and hepatitis B.
FAU - Li, Na
AU  - Li N
AD  - Na Li, Ping Chen, Xu Li, Fei Su, Department of Infectious Diseases, the First 
      Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, 
      China.
FAU - Gao, Yu-Feng
AU  - Gao YF
FAU - Zhang, Tian-Chen
AU  - Zhang TC
FAU - Chen, Ping
AU  - Chen P
FAU - Li, Xu
AU  - Li X
FAU - Su, Fei
AU  - Su F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Hepatol
JT  - World journal of hepatology
JID - 101532469
PMC - PMC3321489
OTO - NOTNLM
OT  - Genetic susceptibility
OT  - Hepatitis B virus
OT  - Interleukin 18
OT  - tagSNP
EDAT- 2012/04/11 06:00
MHDA- 2012/04/11 06:01
PMCR- 2012/03/27
CRDT- 2012/04/11 06:00
PHST- 2011/10/18 00:00 [received]
PHST- 2012/02/29 00:00 [revised]
PHST- 2012/03/17 00:00 [accepted]
PHST- 2012/04/11 06:00 [entrez]
PHST- 2012/04/11 06:00 [pubmed]
PHST- 2012/04/11 06:01 [medline]
PHST- 2012/03/27 00:00 [pmc-release]
AID - 10.4254/wjh.v4.i3.105 [doi]
PST - ppublish
SO  - World J Hepatol. 2012 Mar 27;4(3):105-9. doi: 10.4254/wjh.v4.i3.105.