PMID- 22489945
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120411
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 79
IP  - 5
DP  - 2012 May
TI  - Somatic mutations in the HLA genes of patients with hematological malignancy.
PG  - 359-66
LID - 10.1111/j.1399-0039.2012.01868.x [doi]
AB  - Somatic mutations and genomic alterations are frequent events in the clonal 
      evolution of hematologic malignancies. Recent studies have reported copy neutral 
      loss of heterozygosity (LOH) for the mismatched human leukocyte antigen (HLA) 
      haplotype in patients relapsed after haploidentical hematopoietic cell 
      transplantation (HCT) for a hematologic malignancy. Herein, we report 15 cases of 
      somatic mutations in the HLA genes of patients with a variety of hematologic 
      diseases, including acute myelogenous leukemia, acute lymphocytic leukemia, 
      chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndrome, 
      and non-Hodgkin's lymphoma, encountered at our institute over the past decade. 
      While two of the cases were identified in patient relapse specimens collected 
      post-HCT, 13 cases were found in peripheral blood specimens submitted for HLA 
      typing prior to transplantation. Ten patients exhibited acquired LOH for all or 
      part of one HLA haplotype. Five other cases involved somatic mutations in the 
      nucleotide sequences of common HLA-A or HLA-B alleles. Since they are not 
      systematically evaluated prior to HCT, acquired mutations in HLA genes are likely 
      under reported. Beyond the implications for accurate HLA typing and donor 
      selection, alternations that result in the loss of HLA expression may allow 
      escape from immune surveillance and adversely impact transplant outcome.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Smith, A G
AU  - Smith AG
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 
      USA.
FAU - Fan, W
AU  - Fan W
FAU - Regen, L
AU  - Regen L
FAU - Warnock, S
AU  - Warnock S
FAU - Sprague, M
AU  - Sprague M
FAU - Williams, R
AU  - Williams R
FAU - Nisperos, B
AU  - Nisperos B
FAU - Zhao, L P
AU  - Zhao LP
FAU - Loken, M R
AU  - Loken MR
FAU - Hansen, J A
AU  - Hansen JA
FAU - Pereira, S
AU  - Pereira S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Child
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes
MH  - Hematologic Neoplasms/*genetics
MH  - Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia/*genetics
MH  - Loss of Heterozygosity
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Middle Aged
MH  - Mutation
MH  - Polymorphism, Genetic
EDAT- 2012/04/12 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/04/12 06:00
PHST- 2012/04/12 06:00 [entrez]
PHST- 2012/04/12 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1111/j.1399-0039.2012.01868.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 May;79(5):359-66. doi: 10.1111/j.1399-0039.2012.01868.x.