PMID- 22490043
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20220410
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 90
IP  - 5
DP  - 2012 Aug
TI  - Cytokine concentration in aqueous humour of eyes with exudative age-related 
      macular degeneration.
PG  - e381-8
LID - 10.1111/j.1755-3768.2012.02414.x [doi]
AB  - PURPOSE: To measure the concentration of cytokines in the aqueous humour of eyes 
      with exudative age-related macular degeneration (AMD). METHODS: The clinical 
      interventional study included a study group of 18 patients with exudative AMD and 
      a control group of 20 patients undergoing routine cataract surgery. Age did not 
      vary significantly (p = 0.36) between study group (80.8 +/- 6.4 years) and control 
      group (77.0 +/- 9.9 years), nor did gender (p = 0.75). During the interventions, 
      aqueous humour samples were obtained, in which the concentration of cytokines was 
      measured using a solid-phase chemiluminescence immunoassay. Macular thickness was 
      measured by optical coherence tomography (OCT). RESULTS: In the study group as 
      compared to the control group, significantly higher concentrations were measured 
      for epithelial growth factor (EGF) (p = 0.017), human growth factor (HGF) (p= 
      0.048), intercellular adhesion molecule-1 (ICAM1) (p = 0.028), interleukin 12p40 
      (IL12p40) (p = 0.009), interleukin 1a2 (IL1a2) (p = 0.01), interleukin 3 (IL3) (p 
      = 0.02), interleukin 6 (IL6) (p = 0.006), interleukin 8 (IL8) (p = 0.02), 
      monocyte chemoattractant protein-1 (MCP-1) (p = 0.048), monokine induced by 
      interferon gamma (MIG) (p = 0.016), matrix metalloproteinase 9 (MMP9) (p = 0.004) 
      and plasminogen activator inhibitor 1 (PAI1) (p = 0.006). Macular thickness was 
      significantly associated with the concentrations of EGF (p = 0.001), HGF (p = 
      0.02), ICAM1 (p = 0.001), interleukin 12p40 (p = 0.006), IL 1a2 (p = 0.002), MIG 
      (p = 0.001), MMP9 (p < 0.001) and PAI1 (p = 0.01). Interleukin 6 and MCP-1 showed 
      significant associations with the height of retinal pigment epithelium 
      detachment. CONCLUSIONS: Numerous cytokines are associated with the presence and 
      the amount of exudative AMD.
CI  - (c) 2012 The Authors. Acta Ophthalmologica (c) 2012 Acta Ophthalmologica Scandinavica 
      Foundation.
FAU - Jonas, Jost B
AU  - Jonas JB
AD  - Department of Ophthalmology, Medical Faculty Mannheim of the 
      Ruprecht-Karls-University Heidelberg, Germany. jost.jonas@umm.de
FAU - Tao, Yong
AU  - Tao Y
FAU - Neumaier, Michael
AU  - Neumaier M
FAU - Findeisen, Peter
AU  - Findeisen P
LA  - eng
PT  - Journal Article
DEP - 20120410
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aqueous Humor/*metabolism
MH  - Cataract Extraction
MH  - Cytokines/*metabolism
MH  - Exudates and Transudates
MH  - Female
MH  - Humans
MH  - Luminescent Measurements
MH  - Macula Lutea/pathology
MH  - Male
MH  - Middle Aged
MH  - Tomography, Optical Coherence
MH  - Wet Macular Degeneration/diagnosis/*metabolism
EDAT- 2012/04/12 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/04/12 06:00
PHST- 2012/04/12 06:00 [entrez]
PHST- 2012/04/12 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - 10.1111/j.1755-3768.2012.02414.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2012 Aug;90(5):e381-8. doi: 10.1111/j.1755-3768.2012.02414.x. 
      Epub 2012 Apr 10.